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Variable asialoglycoprotein receptor 1 expression in liver disease: Implications for therapeutic intervention

Dominik Witzigmann1, Luca Quagliata2, Susanne H Schenk1

  • 1Division of Pharmaceutical Technology, Department of Pharmaceutical Sciences, University of Basel, Basel, Switzerland.

Hepatology Research : the Official Journal of the Japan Society of Hepatology
|October 1, 2015
PubMed
Summary

Asialoglycoprotein receptor (ASGPR) targeting for liver disease treatment depends on ASGPR1 expression. This study found ASGPR1 levels vary in liver cancer and cirrhosis, suggesting companion diagnostics are needed for effective therapy.

Keywords:
asialoglycoprotein receptordrug deliveryhepatocyteliver diseasenanomedicine

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