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Is Caenorhabditis elegans the Magic Bullet for Anthelminthic Drug Discovery?

Jennifer Keiser1

  • 1Department of Medical Parasitology and Infection Biology, Swiss Tropical and Public Health Institute, Basel, Switzerland; University of Basel, Basel, Switzerland.

Trends in Parasitology
|October 1, 2015
PubMed

Keywords:
Caenorhabditis elegansanthelminthicsdrug discovery

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Anthelminthic Agents

Anthelmintic drugs differ significantly from antiparasitic therapies targeting protozoa, primarily due to differences in parasite biology. Whereas most protozoal treatments act on proliferating cells, anthelmintics are typically directed against mature, nonproliferative helminths. The therapeutic approach considers the helminth's reliance on neuromuscular coordination, glucose metabolism, and microtubular integrity for survival, reproduction, and localization within the host. Most anthelmintics...
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