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Related Experiment Video

Updated: Apr 1, 2026

Modeling Posthemorrhagic Hydrocephalus of Prematurity in Rats
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[Normal pressure hydrocephalus: A review and practical aspects].

M Mongin1, C Hommet2, K Mondon2

  • 1Service de neurologie, hôpital Bretonneau, CHRU de Tours, 2, boulevard Tonnellé, 37000 Tours, France; Université François-Rabelais, BP 3223, 37032 Tours cedex 01, France.

La Revue De Medecine Interne
|October 1, 2015
PubMed
Summary
This summary is machine-generated.

Idiopathic normal pressure hydrocephalus (iNPH) diagnosis is challenging in the elderly. This review proposes a standard of care, emphasizing MRI and tap tests, while considering Alzheimer's biomarkers for uncertain cases.

Keywords:
BiomarkersBiomarqueurs dans le liquide céphalorachidienCerebrospinal fluid removalDiagnosisDiagnosticHydrocéphalie à pression normale idiopathiqueIdiopathic normal pressure hydrocephalusPonction lombaire soustractiveTraitementTreatment

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Area of Science:

  • Neurology
  • Geriatrics
  • Neurosurgery

Context:

  • Idiopathic normal pressure hydrocephalus (iNPH) is a chronic neurological disorder impacting the elderly population.
  • Diagnosis is complicated by overlapping symptoms with conditions like Alzheimer's disease and microangiopathy.
  • Established diagnostic criteria include Adams and Hakim's triad, ventricular dilation on imaging, and normal cerebrospinal fluid pressure.

Purpose:

  • To establish a comprehensive standard of care for diagnosing idiopathic normal pressure hydrocephalus.
  • To synthesize evidence from 459 articles published over the last decade.
  • To provide guidance for clinicians facing diagnostic challenges in iNPH.

Summary:

  • Brain MRI is crucial for iNPH diagnosis, with specific features predicting positive tap test results and shunt responsiveness.
  • The tap test remains the gold standard for diagnosis, though continuous cerebrospinal fluid drainage offers improved sensitivity.
  • Cerebrospinal fluid Alzheimer's biomarker analysis may aid diagnosis in ambiguous cases, predicting tap test response.

Impact:

  • A standardized approach to iNPH diagnosis can improve patient outcomes.
  • Enhanced diagnostic accuracy leads to more timely and appropriate treatment interventions.
  • This review provides a foundation for future research and clinical guidelines in iNPH management.