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A Thrombotic Stroke Model Based On Transient Cerebral Hypoxia-ischemia
Published on: August 18, 2015
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The relation between oxidative stress parameters, ischemic stroke, and hemorrhagic stroke
Turkish Journal of Medical Sciences
|October 2, 2015
Summary
Oxidative stress markers are elevated in both ischemic and hemorrhagic stroke patients. However, these oxidative stress markers do not appear to influence stroke severity, as measured by the NIH Stroke Scale.
Area of Science:
- Biochemistry
- Neurology
- Clinical Medicine
Background:
- Oxidative stress is implicated in various diseases.
- Its role in stroke pathogenesis requires further elucidation.
Purpose of the Study:
- To assess oxidative stress parameters in ischemic and hemorrhagic stroke.
- To correlate these parameters with stroke severity (NIHSS).
Main Methods:
- Measured total oxidant status (TOS), total antioxidant status (TAS), and other markers in 92 stroke patients and 75 controls.
- Calculated oxidative stress index (OSI) and NIHSS scores.
Main Results:
- TOS and OSI were significantly higher in stroke groups versus controls.
- Arylesterase and thiol levels were lower in the ischemic stroke group.
- No significant correlation was found between oxidative stress markers and NIHSS scores.
Conclusions:
- Oxidative stress likely contributes to the pathogenesis of both stroke types.
- Oxidative stress does not appear to determine stroke severity.
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