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Updated: Apr 1, 2026

Point-Of-Care Ultrasound Screening for Proximal Lower Extremity Deep Venous Thrombosis
Published on: February 10, 2023
Unusual cause of lower extremity wounds: Cobb syndrome
Bahareh Abtahi-Naeini1,2, Ali Saffaei2, Mohsen Pourazizi3
1Skin diseases and Leishmaniasis Research Center, Isfahan University of Medical Sciences, Isfahan, Iran.
Abstract:
Cobb syndrome (Cutaneomeningospinal Angiomatosis) is a rare segmental neurocutaneous syndrome associated with metameric cutaneous and spinal cord arteriovenous malformations (AVMs). In this syndrome, capillary malformation or angiokeratoma-like lesions are formed in a dermatomal distribution, with an AVM in the corresponding segment of the spinal cord. The spinal cord lesions can cause neurological disorder and paraplegia, which typically develop during young adulthood. We report a 32-year-old male with the Cobb syndrome associated with lower extremity painful wounds and acute-onset paraplegia due to metameric vascular malformations.
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