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Related Concept Videos

Modified-Release Drug Delivery Systems: Site-Targeted01:24

Modified-Release Drug Delivery Systems: Site-Targeted

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Site-targeted drug delivery systems enhance therapeutic efficacy while minimizing systemic toxicity and treatment costs. Unlike conventional methods, these systems ensure precise drug delivery, improving bioavailability and reducing side effects. Targeted drug delivery is classified into three levels. First-order targeting directs drugs to the capillary beds of specific organs or tissues. Second-order targets specific cell types, such as tumor cells, using receptor-mediated interactions.
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Site-Targeted Drug Delivery Systems: Polymeric Carriers01:24

Site-Targeted Drug Delivery Systems: Polymeric Carriers

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Polymeric carriers enhance targeted drug delivery by increasing efficacy while minimizing off-target effects. These carriers comprise a biodegradable polymeric backbone integrated with functional elements that enable targeting, improve physicochemical properties, and regulate drug release.Targeting MechanismsThe targeting ability of polymeric carriers is mediated by a homing device, which is a molecular recognition component designed to selectively bind to specific tissues or cells. Monoclonal...
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Updated: Apr 1, 2026

Synthesis of Stimuli-responsive Nanogels using Aqueous One-step Crosslinking and Co-nanopolymerization
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One-component nanomedicine.

Hao Su1, Jin Mo Koo2, Honggang Cui3

  • 1Department of Chemical and Biomolecular Engineering, The Johns Hopkins University, 3400 N Charles Street, Baltimore, MD 21218, USA; Institute for NanoBioTechnology, The Johns Hopkins University, 3400 N Charles Street, Baltimore, MD 21218, USA.

Journal of Controlled Release : Official Journal of the Controlled Release Society
|October 2, 2015
PubMed
Summary
This summary is machine-generated.

One-component nanomedicine (OCN) offers precise control over drug properties by using a single substance. This innovative approach avoids carriers and enables targeted delivery for improved disease treatment.

Keywords:
Drug deliveryNanomedicine

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Area of Science:

  • Nanomedicine
  • Materials Science
  • Drug Delivery

Background:

  • One-component nanomedicine (OCN) is an emerging therapeutic class composed of a single chemical substance.
  • OCN allows precise molecular engineering for optimized drug loading and physicochemical properties.
  • Unlike traditional nanomedicines, OCNs eliminate the need for separate carriers.

Purpose of the Study:

  • To review recent advancements in the molecular design, conjugation, and fabrication of OCNs.
  • To analyze the potential of OCNs for developing improved treatments for severe diseases.
  • To highlight the advantages of OCNs, including self-assembly and inherent targeting capabilities.

Main Methods:

  • Molecular engineering of therapeutic agents (e.g., polymer-drug conjugates, small molecule prodrugs).
  • Utilizing precipitation procedures or molecular assembly strategies for nanostructure formation.
  • Fabrication of nanoscale objects with well-defined sizes and shapes.

Main Results:

  • Demonstrated ability of molecularly crafted agents to self-assemble into OCNs.
  • OCNs exhibit inherent physicochemical properties for preferential accumulation at target sites.
  • Successful development of OCNs through precise molecular design and fabrication.

Conclusions:

  • OCNs represent a promising platform for advanced nanomedicine development.
  • The single-component nature of OCNs facilitates fine-tuning and optimization.
  • OCNs hold significant potential for novel and enhanced therapeutic strategies, particularly in oncology.