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Updated: Apr 1, 2026

A Practical Guide on Coupling a Scanning Mobility Sizer and Inductively Coupled Plasma Mass Spectrometer SMPS-ICPMS
Published on: July 11, 2017
Inductively coupled plasma - Tandem mass spectrometry (ICP-MS/MS): A powerful and universal tool for the
Lieve Balcaen1, Eduardo Bolea-Fernandez1, Martín Resano2
1Ghent University, Department of Analytical Chemistry, Krijgslaan 281-S12, B-9000 Ghent, Belgium.
Abstract:
This paper is intended as a tutorial review on the use of inductively coupled plasma - tandem mass spectrometry (ICP-MS/MS) for the interference-free quantitative determination and isotope ratio analysis of metals and metalloids in different sample types. Attention is devoted both to the instrumentation and to some specific tools and procedures available for advanced method development. Next to the more typical reaction gases, e.g., H2, O2 and NH3, also the use of promising alternative gases, such as CH3F, is covered, and the possible reaction pathways with those reactive gases are discussed. A variety of published applications relying on the use of ICP-MS/MS are described, to illustrate the added value of tandem mass spectrometry in (ultra)trace analysis.
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