Clinical Trials With Mesenchymal Stem Cells: An Update.

Area of Science:

• Regenerative Medicine
• Cell-based Therapies
• Stem Cell Biology

Background:

• Mesenchymal stem cells (MSCs) are adult stem cells with regenerative and differentiation potential.
• Isolation and cultivation protocols vary, leading to heterogeneous cell populations.
• The International Society for Cellular Therapy (ISCT) established criteria for MSC identification.

Purpose of the Study:

• To comprehensively review global Mesenchymal stem cell (MSC)-based clinical trials.
• To scrutinize MSC biological properties and therapeutic effects.
• To highlight clinical findings, trial phases, and criticisms of MSC applications.

Main Methods:

• Review of published literature on Mesenchymal stem cell (MSC) research.
• Analysis of Mesenchymal stem cell (MSC)-based clinical trials from the US National Institutes of Health database.
• Examination of Mesenchymal stem cell (MSC) applications in various disease models.

Main Results:

• 493 Mesenchymal stem cell (MSC)-based clinical trials are documented.
• Mesenchymal stem cells (MSCs) show therapeutic potential across diverse diseases.
• Heterogeneity in Mesenchymal stem cell (MSC) cultures presents challenges.

Conclusions:

• Mesenchymal stem cells (MSCs) offer promising therapeutic avenues for numerous diseases.
• Further standardization of Mesenchymal stem cell (MSC) isolation and characterization is needed.
• Ongoing clinical trials continue to explore the full potential of Mesenchymal stem cells (MSCs).