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[Search for Structurally Unique Bioactive Natural Products].

Naonobu Tanaka1

  • 1Graduate School of Pharmaceutical Sciences, Hokkaido University.

Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan
|October 2, 2015
PubMed
Summary

Marine sponges and Hypericum plants yielded novel natural products. Researchers identified unique alkaloids, sesquiterpenes, triterpenes, meroterpenes, acylphloroglucinols, and xanthones through spectroscopic analysis.

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Area of Science:

  • Natural Product Chemistry
  • Marine Biology
  • Phytochemistry

Context:

  • Marine organisms and plants are rich sources of structurally diverse and biologically active metabolites.
  • Previous research has explored Okinawan marine sponges and Hypericum plants for novel compounds.

Purpose:

  • To isolate and elucidate the structures of new natural products from Okinawan marine sponges and Hypericum plants.
  • To characterize novel alkaloids, sesquiterpenes, triterpenes, meroterpenes, acylphloroglucinols, and xanthones.

Summary:

  • Investigation of marine sponges led to the discovery of novel bromopyrrole alkaloids (nagelamides X-Z), heteroaromatic and bisindole alkaloids (hyrtimomines A-E), an oxylipin (manzamenone O), dimeric sesquiterpenes (halichonadins K-L), and triterpenes (stelliferins J-N).
  • Analysis of Hypericum plants yielded new meroterpenoids (biyoulactones A-E), acylphloroglucinols (chipericumines A-D), prenylated xanthones (biyouxanthones A-D), tricyclic meroterpenes (yezo'otogirins A-C), and linear meroterpenoids (yojironins A and B).
  • Structures were determined using spectroscopic analyses and chemical conversions.

Impact:

  • Expands the known chemical diversity of marine natural products and terrestrial plant metabolites.
  • Provides new molecular scaffolds for potential drug discovery and further biological investigation.
  • Highlights the potential of Okinawan marine sponges and Hypericum species as sources of unique bioactive compounds.