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Updated: Apr 1, 2026

New Tools to Expand Regulatory T Cells from HIV-1-infected Individuals
Published on: May 30, 2013
HIV-1 tuberculosis-associated immune reconstitution inflammatory syndrome
Rachel P J Lai1, Graeme Meintjes2,3,4, Robert J Wilkinson5,6,7,8
1The Francis Crick Institute, Mill Hill Laboratory, London, NW7 1AA, UK.
Abstract:
Patients co-infected with HIV-1 and tuberculosis (TB) are at risk of developing TB-associated immune reconstitution inflammatory syndrome (TB-IRIS) following commencement of antiretroviral therapy (ART). TB-IRIS is characterized by transient but severe localized or systemic inflammatory reactions against Mycobacterium tuberculosis antigens. Here, we review the risk factors and clinical management of TB-IRIS, as well as the roles played by different aspects of the immune response in contributing to TB-IRIS pathogenesis.
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