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miRSponge: a manually curated database for experimentally supported miRNA sponges and ceRNAs
Peng Wang1, Hui Zhi1, Yunpeng Zhang1
1College of Bioinformatics Science and Technology, Harbin Medical University, Harbin 150081, China.
Database : the Journal of Biological Databases and Curation
|October 2, 2015
Summary
We developed miRSponge, a database of experimentally validated microRNA (miRNA) sponges and competing endogenous RNA (ceRNA) interactions. This resource supports research into miRNA regulation in biological and pathological processes.
Area of Science:
- Molecular Biology
- Genomics
- Bioinformatics
Background:
- MicroRNAs (miRNAs) regulate gene expression by binding to target mRNAs.
- Competing endogenous RNAs (ceRNAs), or miRNA sponges, can sequester miRNAs, modulating their activity.
- Understanding miRNA-ceRNA interactions is crucial for various biological and pathological processes.
Purpose of the Study:
- To establish miRSponge, a manually curated, experimentally supported database for miRNA sponges and ceRNA relationships.
- To provide a centralized resource for researchers studying miRNA sponging mechanisms.
Main Methods:
- Manual curation of nearly 1200 published articles.
- Data extraction on miRNA-sponge interactions and ceRNA relationships.
- Inclusion of diverse endogenous and exogenous RNA molecules.
Main Results:
- The miRSponge database contains 599 miRNA-sponge interactions and 463 ceRNA relationships across 11 species.
- Data includes coding genes, pseudogenes, lncRNAs, circRNAs, viral RNAs, and engineered sponges.
- Approximately 70% of interactions were experimentally validated in disease contexts.
Conclusions:
- miRSponge offers a valuable, experimentally validated resource for miRNA sponge research.
- The database facilitates browsing, retrieval, and downloading of ceRNA data.
- A submission portal encourages community contribution of new findings.
