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Updated: Apr 1, 2026

Application of High-speed Super-resolution SPEED Microscopy in Live Primary Cilium
Published on: January 16, 2018
Ciliary subcompartments and cysto-proteins
1Division of Developmental Biology, Department of Anatomy, Kyoto Prefectural University of Medicine, 465 Kajii-cho, Hirokoji, Kawara-machi, Kamigyo-ku, Kyoto, 602-8566, Japan. tyoko@koto.kpu-m.ac.jp.
Abstract:
Renal cystic diseases are conditions in which parts of or entire nephrons become enlarged and create fluid-filled cysts. These cysts occur in many genetic diseases. Most of the products of causative genes, termed cysto-proteins, are localized in cilia and/or centrioles. In addition, mutant mice lacking cilia develop renal cysts. Therefore, cilia are thought to have an important role in renal cystogenesis. The cilium is a tiny projection from the cell surface; however, it can be divided into several subcompartments. These subcompartments have specific roles. This review attempts to classify cysto-proteins based on their localization in ciliary subcompartments with the aim of defining relationships among them and of identifying their exact intraciliary functions.
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