Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Development of Immunocompetence01:22

Development of Immunocompetence

1.2K
The initiation of cell-mediated immunity can be observed as early as the third month of fetal growth, with active antibody-mediated immunity following approximately one month later.
The initial cells that migrate from the fetal thymus settle within the skin and epithelial tissues lining the mouth, digestive tract, and in females, the uterus and vagina. These cells, including skin-based dendritic cells, serve as antigen-presenting cells, playing a key role in T cell activation.
Subsequent T...
1.2K
Immunological Memory01:23

Immunological Memory

17.9K
Immunological memory, a pivotal pillar of the adaptive immune system, is responsible for the body's ability to remember and respond more swiftly and effectively to previously encountered pathogens. This remarkable feature is what makes vaccines so effective in preventing diseases.
What is Immunological Memory?
Immunological memory is an integral function of the immune system that allows it to recognize and react more rapidly and effectively to pathogens previously encountered. This feature...
17.9K
Immune Response Against Viral Pathogens01:29

Immune Response Against Viral Pathogens

2.5K
The immune system's response to viral infections is a complex and coordinated process involving natural killer (NK) cells, T cell-mediated responses, and antibody-mediated responses.
NK Cells
NK cells are a crucial part of our innate immune system, acting as the first line of defense against viral infections. These cells can recognize and kill infected cells without prior exposure to the virus, effectively slowing down the spread of infection. Additionally, NK cells produce proinflammatory...
2.5K
B Cell Activation and Differentiation01:24

B Cell Activation and Differentiation

18.4K
The adaptive immune response, a sophisticated defense mechanism, relies on the activation and differentiation of B lymphocytes, or B cells. These processes enable our bodies to mount a tailored response against specific pathogens such as bacteria, free virus particles, toxins, and parasites.
When naive B cells encounter a specific antigen that can bind to the B cell receptor (BCR) on their surface, they undergo sensitization to respond to the antigen's presence. Sensitization begins with...
18.4K
Special Features of Adaptive Immunity01:20

Special Features of Adaptive Immunity

4.4K
The adaptive immune system, a crucial component of the overall immune response, offers a highly specialized defense against pathogens. It involves specific cell types and features, enabling it to combat infections effectively and efficiently.
The primary cell types involved in adaptive immunity are T cells and B cells. Each type has a unique role in defending the body against pathogens. T cells are responsible for cell-mediated immunity. They identify and eliminate infected cells directly,...
4.4K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

The ASSIST CLAD study: A phase 2 randomized controlled trial of mesenchymal stromal cells for new-onset chronic lung allograft dysfunction.

The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation·2026
Same author

Dual-pumping supercontinuum generation and temporal reflection in a nonlinear photonic integrated circuit.

Optics express·2026
Same author

Scalable photonic reservoir computing for parallel machine learning tasks.

Nature communications·2025
Same author

Supercontinuum generation in high-index doped silica photonic integrated circuits under diverse pumping settings.

Optics express·2025
Same author

Mid-infrared nonlinear optical response of Si-Ge waveguides with ultra-short optical pulses.

Optics express·2015
Same author

Nonlinear optical response of low loss silicon germanium waveguides in the mid-infrared.

Optics express·2015

Related Experiment Video

Updated: Apr 1, 2026

Separation of Immune Cell Subpopulations in Peripheral Blood Samples from Children with Infectious Mononucleosis
08:44

Separation of Immune Cell Subpopulations in Peripheral Blood Samples from Children with Infectious Mononucleosis

Published on: September 7, 2022

3.0K

EBV-Specific Immune Response: Early Research and Personal Reminiscences.

D J Moss1, V P Lutzky2

  • 1QIMR Berghofer Medical Research Institute, Brisbane, Australia. denis.moss@qimrberghofer.edu.au.

Current Topics in Microbiology and Immunology
|October 2, 2015
PubMed
Summary

Early research on Epstein-Barr virus (EBV) linked it to diseases like infectious mononucleosis (IM) through antibody responses. Later, studies revealed a specific T cell memory response controlling EBV-infected B cells.

More Related Videos

Generation of Multivirus-specific T Cells to Prevent/treat Viral Infections after Allogeneic Hematopoietic Stem Cell Transplant
08:52

Generation of Multivirus-specific T Cells to Prevent/treat Viral Infections after Allogeneic Hematopoietic Stem Cell Transplant

Published on: May 27, 2011

17.9K
Isolation and Quantification of Epstein-Barr Virus from the P3HR1 Cell Line
09:14

Isolation and Quantification of Epstein-Barr Virus from the P3HR1 Cell Line

Published on: September 28, 2022

4.8K

Related Experiment Videos

Last Updated: Apr 1, 2026

Separation of Immune Cell Subpopulations in Peripheral Blood Samples from Children with Infectious Mononucleosis
08:44

Separation of Immune Cell Subpopulations in Peripheral Blood Samples from Children with Infectious Mononucleosis

Published on: September 7, 2022

3.0K
Generation of Multivirus-specific T Cells to Prevent/treat Viral Infections after Allogeneic Hematopoietic Stem Cell Transplant
08:52

Generation of Multivirus-specific T Cells to Prevent/treat Viral Infections after Allogeneic Hematopoietic Stem Cell Transplant

Published on: May 27, 2011

17.9K
Isolation and Quantification of Epstein-Barr Virus from the P3HR1 Cell Line
09:14

Isolation and Quantification of Epstein-Barr Virus from the P3HR1 Cell Line

Published on: September 28, 2022

4.8K

Area of Science:

  • Virology
  • Immunology
  • Oncology

Background:

  • Early Epstein-Barr virus (EBV) research focused on serological responses.
  • Antibody patterns to EBV antigens (MA, EA, EBNA) were key to linking EBV with infectious mononucleosis (IM), Burkitt's lymphoma (BL), and nasopharyngeal carcinoma (NPC).

Observation:

  • The lymphocytosis in acute IM was noted to be T cell-dominated.
  • T cells from acute IM patients underwent apoptosis shortly after blood separation.
  • EBV-infected cultures from immune individuals showed regression around 10 days post-seeding, indicating a memory response.

Findings:

  • Initial studies debated whether T cell responses controlling EBV were non-specific or HLA non-restricted.
  • The regression of EBV-infected cells provided the first evidence of a specific memory T cell response.
  • Initially, CD8(+) T cells were implicated, with later research suggesting a role for CD4(+) T cells.

Implications:

  • Understanding EBV's serological and cellular immune responses is crucial for disease association studies.
  • The discovery of a specific memory T cell response highlights the adaptive immune system's role in controlling latent EBV infection.
  • This historical review provides insights into the early development of EBV immunology and its clinical relevance.