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Viral Recombination

Viral Recombination

Cells are sometimes infected by more than one virus at once. When two viruses disassemble to expose their genomes for replication in the same cell, similar regions of their genomes can pair together and exchange sequences in a process called recombination. Alternatively, viruses with segmented genomes can swap segments in a process called reassortment.

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Updated: Apr 1, 2026

Isolation and Quantification of Epstein-Barr Virus from the P3HR1 Cell Line

Isolation and Quantification of Epstein-Barr Virus from the P3HR1 Cell Line

Published on: September 28, 2022

Epstein-Barr Virus Strain Variation.

Paul J Farrell¹

¹Section of Virology, Department of Medicine, Imperial College, St Mary's Campus, Norfolk Place, London, W2 1PG, UK. p.farrell@imperial.ac.uk.

Current Topics in Microbiology and Immunology

|October 2, 2015

Summary

This summary is machine-generated.

Wild-type Epstein-Barr virus (EBV) strains show genetic differences, primarily classified as type 1 and type 2 based on the EBNA2 gene. These variations influence B cell transformation efficiency, potentially impacting EBV-associated diseases.

Keywords:

DNA sequence Epstein–barr virus Genome Strain Variation

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Area of Science:

Virology
Genetics
Immunology

Background:

Epstein-Barr virus (EBV) is a widespread human herpesvirus.
Understanding EBV strain diversity is crucial for comprehending EBV-associated diseases.
Recent advancements in DNA sequencing provide new insights into EBV genetic variations.

Purpose of the Study:

To explore the genetic differences between wild-type Epstein-Barr virus (EBV) strains.
To investigate how EBV strain variations contribute to EBV-associated diseases.
To understand the molecular mechanisms behind differential B cell transformation by EBV types.

Main Methods:

Analysis of newly available Epstein-Barr virus (EBV) genome sequences.
Classification of EBV isolates into type 1 and type 2 based on EBNA2 gene sequences.
Investigating geographic variations and relationships between viral strains and disease.

Main Results:

EBV isolates are broadly classified into type 1 and type 2 based on EBNA2 gene sequences.
Type 1 EBV exhibits significantly higher efficiency in transforming human B cells compared to type 2.
Molecular mechanisms underlying this transformation difference are being elucidated.

Conclusions:

Genetic variations in Epstein-Barr virus (EBV) strains, particularly the EBNA2 gene, play a role in B cell transformation.
Further research into viral sequence variation is warranted to understand its role in EBV-associated disease incidence.
The study highlights the importance of considering EBV strain diversity in disease pathogenesis.