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Related Concept Videos

Yeast Signaling01:28

Yeast Signaling

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Yeasts are single-celled organisms, but unlike bacteria, they are eukaryotes (cells with a nucleus). Cell signaling in yeast is similar to signaling in other eukaryotic cells. A ligand, such as a protein or a small molecule released from a yeast cell, attaches to a receptor on the cell surface. The binding stimulates second-messenger kinases to activate or inactivate transcription factors that further regulate gene expression. Many of the yeast intracellular signaling cascades have similar...
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Genome-wide Profiling of Transcription Factor-DNA Binding Interactions in Candida albicans: A Comprehensive CUT&RUN Method and Data Analysis Workflow
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Budding off: bringing functional genomics to Candida albicans.

Matthew Z Anderson, Richard J Bennett

    Briefings in Functional Genomics
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    PubMed
    Summary

    Functional genomics advances Candida albicans research, enabling global studies of gene function. These methods explore its dual role as a commensal and a pathogen, improving understanding of fungal infections.

    Keywords:
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    Area of Science:

    • Mycology
    • Genomics
    • Infectious Diseases

    Background:

    • Candida species are common human fungal pathogens, with Candida albicans being the most significant.
    • Candida albicans exists as a commensal in the human gut but can cause opportunistic mucosal and systemic infections.

    Purpose of the Study:

    • To highlight the development of functional genomics in Candida albicans.
    • To discuss the application of these genomic approaches in studying commensalism and pathogenesis.

    Main Methods:

    • Comparative genomics (inter- and intra-species).
    • Analysis of total RNA expression.
    • Delineation of protein-DNA interactions.
    • Systematic screening of mutant strains for clinically relevant phenotypes.

    Main Results:

    • Functional genomics enables global, unbiased studies of gene function in Candida albicans.
    • Advances facilitate a deeper understanding of virulence factors and host-pathogen interactions.
    • Large mutant collections aid in screening for significant phenotypes.

    Conclusions:

    • Functional genomics has revolutionized the study of Candida albicans.
    • These approaches are crucial for understanding the complex biology of Candida albicans, from commensalism to infection.