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Vitamin D as a marker of cognitive decline in elderly Indian population
Tejal Kanhaiya Vedak1, Vaishali Ganwir2, Arun B Shah3
1Ph.D. Student, Applied Biology (Immunology), Sir H. N. Medical Research Society and Sir H. N. Reliance Foundation Hospital and Research Centre, Girgaum, Mumbai, Maharashtra, India.
Objectives:
Very few studies in India have addressed the role of vitamin D in cognitive function. The present study was conducted to assess the serum levels of 25-hydroxyvitamin D (25(OH)D) and its association with markers of cognitive impairment and homocysteine levels in the elderly Indian population.
Materials And Methods:
The study population consisted of patients with dementia (Group A, n = 32), mild cognitive impairment (MCI; Group B, n = 24), and elderly age-matched controls (Group C, n = 30). Measurement of serum levels of 25(OH)D and total homocysteine were done.
Results:
Significant decreased concentration of 25(OH)D and increased concentration of homocysteine was observed. Association of serum levels of vitamin D with markers of cognitive decline as well as serum homocysteine levels was observed in patients with dementia and MCI when compared to controls.
Conclusion:
Correlation of vitamin D with markers of cognitive decline and homocysteine opens a new door for early diagnosis of cognitive impairment.
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