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Updated: Apr 1, 2026
09:54
Chronic, Acute, and Reactivated HIV Infection in Humanized Immunodeficient Mouse Models
Published on: December 3, 2019
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A case study of human immunodeficiency virus with positive seroconversion to negative
V Paranthaman1, H L Yip2, H B Ker3
1Paranthaman Vengadasalam (Corresponding author) Family Medicine Specialist, Jelapang Health Clinic, Ipoh, Malaysia
Summary
A case study highlights a human immunodeficiency virus (HIV) positive diagnosis reversal in an ex-intravenous drug user (IVDU). This suggests molecular retesting for high-risk individuals with unexpected stable CD4 counts.
Area of Science:
- Clinical Medicine
- Infectious Diseases
- Immunology
Background:
- Enzyme Immunoassay (EIA) is a common method for initial human immunodeficiency virus (HIV) screening.
- Accurate HIV diagnosis is crucial for timely treatment and patient management.
Observation:
- A 36-year-old ex-intravenous drug user (IVDU) initially tested HIV-positive via Enzyme Immunoassay (EIA).
- The patient remained asymptomatic with stable T helper cells (CD4) counts.
- A subsequent test a year later revealed an HIV-negative status.
Findings:
- This case presents a diagnostic discrepancy where an initial HIV-positive result was later invalidated.
- The unexpected clinical course, marked by stable CD4 counts, warrants further investigation into diagnostic accuracy.
Implications:
- Consider molecular methods for retesting high-risk individuals initially diagnosed as HIV-positive, especially those with stable CD4 counts.
- This approach may improve diagnostic accuracy and prevent misdiagnosis in complex cases.
- Further research is needed to understand the mechanisms behind such diagnostic reversals.
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