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Updated: Apr 1, 2026

Assessing Lysosomal Alkalinization in the Intestine of Live Caenorhabditis elegans
Published on: April 13, 2018
Carnosine and Related Peptides: Therapeutic Potential in Age-Related Disorders
José H Cararo1, Emilio L Streck2, Patricia F Schuck1
11 Laboratório de Erros Inatos do Metabolismo, Programa de Pós-Graduaçãoem Ciências da Saúde, Universidade do Extremo Sul Catarinense, Criciúma, SC, Brazil.
Abstract:
Imidazole dipeptides (ID), such as carnosine (β-alanyl-L-histidine), are compounds widely distributed in excitable tissues of vertebrates. ID are also endowed of several biochemical properties in biological tissues, including antioxidant, bivalent metal ion chelating, proton buffering, and carbonyl scavenger activities. Furthermore, remarkable biological effects have been assigned to such compounds in age-related human disorders and in patients whose activity of serum carnosinase is deficient or undetectable. Nevertheless, the precise biological role of ID is still to be unraveled. In the present review we shall discuss some evidences from clinical and basic studies for the utilization of ID as a drug therapy for age-related human disorders.
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