Rational design of enzyme inhibitors: multisubstrate analogue inhibitors

5,6-Diaminocytidine, a versatile synthon for pyrimidine-based bicyclic nucleosides.

Organic letters·2000

PMTI, a broadly active unusual single-stranded polyribonucleotide, inhibits human immunodeficiency virus replication by multiple mechanisms.

Antiviral chemistry & chemotherapy·1999

Antiviral oligo- and polyribonucleotides containing selected triazolo[2,3-a]purines.

Journal of medicinal chemistry·1998

Nonclassical 2,4-diamino-8-deazafolate analogues as inhibitors of dihydrofolate reductases from rat liver, Pneumocystis carinii, and Toxoplasma gondii.

Journal of medicinal chemistry·1996

Probing nucleic acid geometries: oligonucleotides containing 2'-O-phenethyladenosine at specific sites.

Bioconjugate chemistry·1996

Self-complementary oligodeoxyribonucleotides containing 2'-O-(anthraquinone-2-methyl)adenosine.

Bioconjugate chemistry·1995

Structural and Mechanistic Studies of ADEPs Yield Potent Antibacterials and a Drug Formulation Strategy for Tuberculosis.

Journal of medicinal chemistry·2026

A 177Lu-Labeled Circular Bivalent Aptamer for PTK7-Targeting Radionuclide Therapy in Ovarian Cancer and Orthotopic Hepatoblastoma.

Journal of medicinal chemistry·2026

From Fragment Hit to Clinical Candidate: Discovery of Dual H1R/H4R Ligands with Superior Efficacy in Allergic Conjunctivitis.

Journal of medicinal chemistry·2026

Potent Anticancer Tethered Organorhodium(III) Complexes Target the Mitochondria.

Journal of medicinal chemistry·2026

Discovery of a Covalent NLRP3 LRR-Domain Probe: Reversing Renal Fibrosis via Immunometabolic Reprogramming in Organoid and Murine Models.

Journal of medicinal chemistry·2026

Lead Optimization of Multimutant KRAS Switch-II Pocket Macrocyclic Inhibitors via Isosteric Replacement to Improve ADME and Oral Exposure.

Journal of medicinal chemistry·2026

HD-SKRG: a hierarchical dual-view and structure-knowledge relation graph enhancement network for few-shot molecular property prediction.

Molecular diversity·2026

Preclinical development of ABL206, a novel bispecific antibody-drug conjugate targeting B7-H3 and ROR1.

mAbs·2026

MLI-DTA: An interpretable multimodal framework with multi-level interactions for drug-target affinity prediction.

European journal of medicinal chemistry·2026

Synthesis and biological activity of steroid conjugates of five-membered N-heterocycles with one or two nitrogen atoms: A review covering the years 2020-2025.

European journal of medicinal chemistry·2026

Organotin-Catalyzed Synthesis, Characterization, Anticancer and Antioxidant Activities, and Molecular Modeling Studies of Nimesulide Ureas as Potential MetAP (Type II) Inhibitors.

ACS omega·2026

Related Experiment Videos

Rational design of enzyme inhibitors: multisubstrate analogue inhibitors

Related Concept Videos

5,6-Diaminocytidine, a versatile synthon for pyrimidine-based bicyclic nucleosides.

PMTI, a broadly active unusual single-stranded polyribonucleotide, inhibits human immunodeficiency virus replication by multiple mechanisms.

Antiviral oligo- and polyribonucleotides containing selected triazolo[2,3-a]purines.

Nonclassical 2,4-diamino-8-deazafolate analogues as inhibitors of dihydrofolate reductases from rat liver, Pneumocystis carinii, and Toxoplasma gondii.

Probing nucleic acid geometries: oligonucleotides containing 2'-O-phenethyladenosine at specific sites.

Self-complementary oligodeoxyribonucleotides containing 2'-O-(anthraquinone-2-methyl)adenosine.

Structural and Mechanistic Studies of ADEPs Yield Potent Antibacterials and a Drug Formulation Strategy for Tuberculosis.

A 177Lu-Labeled Circular Bivalent Aptamer for PTK7-Targeting Radionuclide Therapy in Ovarian Cancer and Orthotopic Hepatoblastoma.

From Fragment Hit to Clinical Candidate: Discovery of Dual H1R/H4R Ligands with Superior Efficacy in Allergic Conjunctivitis.

Potent Anticancer Tethered Organorhodium(III) Complexes Target the Mitochondria.

Discovery of a Covalent NLRP3 LRR-Domain Probe: Reversing Renal Fibrosis via Immunometabolic Reprogramming in Organoid and Murine Models.

Lead Optimization of Multimutant KRAS Switch-II Pocket Macrocyclic Inhibitors via Isosteric Replacement to Improve ADME and Oral Exposure.

HD-SKRG: a hierarchical dual-view and structure-knowledge relation graph enhancement network for few-shot molecular property prediction.

Preclinical development of ABL206, a novel bispecific antibody-drug conjugate targeting B7-H3 and ROR1.

MLI-DTA: An interpretable multimodal framework with multi-level interactions for drug-target affinity prediction.

Synthesis and biological activity of steroid conjugates of five-membered N-heterocycles with one or two nitrogen atoms: A review covering the years 2020-2025.

Organotin-Catalyzed Synthesis, Characterization, Anticancer and Antioxidant Activities, and Molecular Modeling Studies of Nimesulide Ureas as Potential MetAP (Type II) Inhibitors.

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Rational design of enzyme inhibitors: multisubstrate analogue inhibitors

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