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Peripheral Artery Disease (PAD) is characterized by narrowed arteries that diminish blood flow to the extremities. Effective management of PAD requires an interprofessional approach involving various healthcare professionals. The critical aspects of interprofessional care for PAD patients focus on risk factor modification, drug therapy, exercise therapy, nutrition therapy, critical limb ischemia care, and interventional radiology and surgical procedures.The primary treatment goal for PAD...
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Related Experiment Video

Updated: Apr 1, 2026

Knee Arthrocentesis in Adults
04:41

Knee Arthrocentesis in Adults

Published on: February 25, 2022

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Clopidogrel-Induced Recurrent Polyarthritis.

Sahil Agrawal1, Joseph Harburger2, Gary Stallings1

  • 1Department of Internal Medicine, Westchester Medical Center, New York Medical College, Valhalla, NY, USA.

Journal of Investigative Medicine High Impact Case Reports
|October 2, 2015
PubMed
Summary
This summary is machine-generated.

Clopidogrel, used in dual antiplatelet therapy, may cause recurrent arthritis. Symptoms resolved upon drug discontinuation and did not recur with prasugrel, suggesting a potential link.

Keywords:
arthralgiaarthritisclopidogrelplavix

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Last Updated: Apr 1, 2026

Knee Arthrocentesis in Adults
04:41

Knee Arthrocentesis in Adults

Published on: February 25, 2022

10.4K

Area of Science:

  • Cardiology
  • Pharmacology
  • Rheumatology

Background:

  • Clopidogrel is a P2Y12 inhibitor used in dual antiplatelet therapy (DAPT) to prevent stent thrombosis.
  • Common adverse effects include bleeding, neutropenia, and rash; arthralgia and backache are also reported.
  • Previous case reports have suggested a link between clopidogrel and arthritis.

Purpose of the Study:

  • To report a case of recurrent arthritis potentially associated with clopidogrel therapy.
  • To highlight the diagnostic challenge and management of drug-induced arthritis.

Main Methods:

  • A case report of a 64-year-old male patient experiencing fever and joint pain after initiating clopidogrel.
  • Clinical evaluation including assessment of acute-phase reactants, laboratory tests, and radiologic imaging.
  • Review of patient's prior medical history for similar reactions.
  • Observation of symptom response to clopidogrel discontinuation and subsequent treatment with prasugrel.

Main Results:

  • The patient developed fever and joint pains attributed to clopidogrel initiation.
  • Acute-phase reactants were elevated; laboratory and radiologic findings were unremarkable.
  • The patient had a similar episode of arthritis after a previous clopidogrel exposure.
  • Symptoms resolved significantly after discontinuing clopidogrel, with no recurrence upon switching to prasugrel.

Conclusions:

  • Clopidogrel may be associated with recurrent drug-induced arthritis.
  • This case adds to the limited evidence suggesting a potential link between clopidogrel and arthritis.
  • Prasugrel may be a suitable alternative in patients experiencing clopidogrel-induced arthritis.