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Glaucoma is an eye condition characterized by increased intraocular pressure that damages the retina and optic nerve, leading to irreversible blindness if left untreated. The human eye has various components, including the cornea, iris, pupil, lens, and optic nerve. Aqueous humor is secreted by the epithelium of the ciliary body in the posterior chamber and flows through the trabecular meshwork and canal of Schlemm, maintaining normal intraocular pressure. The trabecular meshwork and the canal...
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Related Experiment Video

Updated: Apr 1, 2026

Full-Circle Cauterization of Limbal Vascular Plexus for Surgically Induced Glaucoma in Rodents
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Glaucomatous-Type Optic Discs in High Myopia.

Natsuko Nagaoka1, Jost B Jonas2, Kei Morohoshi1

  • 1Department of Ophthalmology and Visual Science, Tokyo Medical and Dental University, 1-5-45 Yushima, Bunkyo-ku, Tokyo, 113-8519, Japan.

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|October 2, 2015
PubMed
Summary
This summary is machine-generated.

Glaucoma risk increases with larger optic disc size in highly myopic individuals. This study found that large optic discs in high myopia are linked to a 3.2 times higher risk of glaucoma.

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Area of Science:

  • Ophthalmology
  • Medical Research

Background:

  • High myopia is a significant risk factor for various ocular pathologies.
  • Glaucoma is a leading cause of irreversible blindness worldwide.
  • Understanding glaucoma prevalence in high myopia is crucial for early detection and management.

Purpose of the Study:

  • To determine the prevalence of glaucoma in patients diagnosed with high myopia.
  • To investigate the association between ocular parameters and glaucoma in this population.

Main Methods:

  • A hospital-based observational study was conducted on 172 patients (336 eyes) with high myopia.
  • High myopia was defined as a refractive error greater than -8 diopters or axial length ≥26.5 mm.
  • Glaucoma was diagnosed based on optic disc appearance and visual field defects, excluding myopic macular changes.

Main Results:

  • Glaucoma was detected in 28% of the eyes studied.
  • A larger optic disc area was significantly associated with longer axial length.
  • Glaucoma prevalence was 3.2 times higher in eyes with megalodiscs (>3.79 mm²) compared to normal or small discs, even after adjusting for age.

Conclusions:

  • In highly myopic individuals, glaucoma prevalence is associated with increased optic disc size, particularly beyond 3.8 mm².
  • Highly myopic individuals with megalodiscs face a 3.2-fold higher risk of glaucomatous optic neuropathy.
  • The elevated glaucoma risk in axial high myopia is primarily linked to disc enlargement, not axial elongation itself.