Related Experiment Video
Updated: Apr 1, 2026
Fabrication of High Contact-Density, Flat-Interface Nerve Electrodes for Recording and Stimulation Applications
Published on: October 4, 2016
Self-organization of "fibro-axonal" composite tissue around unmodified metallic micro-electrodes can form a
Amitabha Lahiri1, Ignacio Martinez Delgado2, Swathi Sheshadri2
1Yong Loo Lin School of Medicine, National University of Singapore, Singapore.
Introduction:
A long-term peripheral neural interface is an area of intense research. The use of electrode interfaces is limited by the biological response to the electrode material.
Methods:
We created an electrode construct to harbor the rat sciatic nerve with interposition of autogenous adipose tissue between the nerve and the electrode. The construct was implanted for 10 weeks.
Results:
Immunohistochemistry showed a unique laminar pattern of axonal growth layered between fibro-collagenous tissue, forming a physical interface with the tungsten micro-electrode. Action potentials transmitted across the intrerface showed mean conduction velocities varying between 6.99 ± 2.46 and 20.14 ± 4 m/s.
Conclusions:
We have demonstrated the feasibility of a novel peripheral nerve interface through modulation of normal biologic phenomena. It has potential applications as a chronic implantable neural interface.
More Related Videos
10:45Anatomically Inspired Three-dimensional Micro-tissue Engineered Neural Networks for Nervous System Reconstruction, Modulation, and Modeling
Published on: May 31, 2017
10:35Fabrication of the Composite Regenerative Peripheral Nerve Interface C-RPNI in the Adult Rat
Published on: February 25, 2020