Amination of Aryl Halides and Esters Using Intensified Continuous Flow Processing

Area of Science:

• Organic Chemistry
• Chemical Engineering
• Process Chemistry

Background:

• Amination reactions involving aryl halides and esters are crucial in organic synthesis.
• Traditional batch methods for these reactions can be challenging, especially at elevated temperatures.
• Process intensification offers potential solutions for improving efficiency and safety.

Purpose of the Study:

• To demonstrate significant process intensification for amination reactions using continuous flow processing.
• To enable the safe execution of traditionally difficult amination reactions at elevated temperatures.
• To evaluate the scalability of continuous flow amination from laboratory to preparatory scales.

Main Methods:

• Utilized continuous flow reactor technology for amination reactions.
• Employed laboratory scale coil reactor modules (1 mm internal diameter).
• Scaled up the process using a preparatory scale tubular reactor (6 mm internal diameter) with static mixers.

Main Results:

• Achieved significant process intensification for amination of aryl halides and esters.
• Successfully performed difficult amination reactions safely at elevated temperatures.
• Demonstrated successful reaction conduct across different scales, from laboratory to preparatory.

Conclusions:

• Continuous flow processing is a viable and effective technology for process intensification of amination reactions.
• The methodology allows for safe operation at elevated temperatures, expanding reaction capabilities.
• The approach is scalable, showing promise for industrial applications.