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A Microfluidic-based Electrochemical Biochip for Label-free DNA Hybridization Analysis
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Ultratrace DNA Detection Based on the Condensing-Enrichment Effect of Superwettable Microchips
Li-Ping Xu1, Yanxia Chen1, Gao Yang2
1Research Center for Bioengineering and Sensing Technology, University of Science & Technology Beijing, Beijing, 100083, P. R. China.
Advanced Materials (Deerfield Beach, Fla.)
|October 2, 2015
Abstract:
A sensitive nucleic acid detection platform based on superhydrophilic microwells spotted on a superhydrophobic substrate is fabricated. Due to the wettability differences, ultratrace DNA molecules are enriched and the fluorescent signals are amplified to allow more sensitive detection. The biosensing interface based on superwettable materials provides a simple and cost-effective way for ultratrace DNA sensing.
