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Tetrahydrocannabinol (THC) is a phytocannabinoid that primarily interacts with the CB1 receptor, a type of G protein-coupled receptor (GPCR) predominantly in and around the chemoreceptor trigger zone (CTZ) and emetic center. THC also blocks the serotonin receptor activity in the dorsal vagal complex (DVC) by inhibiting serotonin release. THC exerts its anti-emetic effects through these interactions, which are beneficial for patients undergoing chemotherapy.
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Psychoactive drugs impact brain function, influencing perception, mood, consciousness, cognition, and behavior. These substances are grouped based on their effects and the mechanisms by which they act.
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Hallucinogens are psychoactive substances that profoundly alter perceptual experiences, generating unreal visual and sensory images. Often referred to as psychedelic drugs — a term derived from the Greek words "psyche" (mind) and "delos" (revealing) — these substances include marijuana and lysergic acid diethylamide (LSD), among others. These drugs vary in intensity and effects.
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Related Experiment Video

Updated: Apr 1, 2026

Non-Aqueous Isolation and Enrichment of Glandular Capitate Stalked and Sessile Trichomes from Cannabis sativa
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Cannabis - the Israeli perspective.

Raphael Mechoulam

    Journal of Basic and Clinical Physiology and Pharmacology
    |October 2, 2015
    PubMed
    Summary

    This study reviews historical cannabis use and current research on phytocannabinoids and the endocannabinoid system, highlighting Israeli contributions. It also details cannabinoid research projects and Israel

    Area of Science:

    • Pharmacology
    • Medical Research
    • History of Medicine

    Background:

    • Explores the historical applications of cannabis in the Middle East.
    • Introduces the endocannabinoid system and phytocannabinoids in scientific research.
    • Highlights significant research contributions from Israel in cannabinoid science.

    Purpose of the Study:

    • To provide an overview of cannabis history and modern cannabinoid research.
    • To emphasize Israel's role in advancing the scientific understanding of phytocannabinoids.
    • To report on current cannabinoid research projects, clinical trials, and medical marijuana regulation in Israel.

    Main Methods:

    • Literature review of historical cannabis use.
    • Summary of current scientific and medical research on phytocannabinoids and the endocannabinoid system.

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  • Overview of Israeli research contributions and regulatory status of medical marijuana.

    • Main Results:

    • Cannabis has a long history of use in the Middle East.
    • Significant scientific and medical research on phytocannabinoids and the endocannabinoid system is ongoing, with notable contributions from Israel.
    • Israel has a regulated medical marijuana program serving over 22,000 patients, with active research and clinical trials.

    Conclusions:

    • The study underscores the evolving understanding of cannabis and cannabinoids in both historical and modern scientific contexts.
    • Israel is a key player in advancing cannabinoid research and its medical applications.
    • The regulation and administration of medical marijuana in Israel demonstrate its growing acceptance and therapeutic use.