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Transgenic Rodent Assay for Quantifying Male Germ Cell Mutant Frequency

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Published on: August 6, 2014

A Chemical Mutagenesis Screen Identifies Mouse Models with ERG Defects.

Jeremy R Charette¹, Ivy S Samuels², Minzhong Yu³

¹The Jackson Laboratory, 04609, Bar Harbor, ME, USA. Jeremy.Charette@jax.org.

Advances in Experimental Medicine and Biology

|October 3, 2015

Summary

New mouse models for vision research, including Grm1, Grk1, and Lrit3, have been identified. These models exhibit electroretinogram defects and are freely available for scientific study.

Keywords:

Electroretinogram Mice Mutagenesis Photoreceptor Retina

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Area of Science:

Ophthalmology
Genetics
Neuroscience

Background:

Mouse models are crucial for advancing vision research, particularly in retinal development, function, and disease.
The Translational Vision Research Models (TVRM) program actively generates novel mouse models through chemical mutagenesis.

Purpose of the Study:

To report the identification and characterization of new mouse models for vision research.
To make these valuable research tools available to the scientific community.

Main Methods:

Chemical mutagenesis was employed to generate new mouse models.
Phenotypic characterization included electroretinogram (ERG) analysis to identify visual function defects.

Main Results:

Novel mouse models for the genes Grm1, Grk1, and Lrit3 were identified.
Each identified model displayed a primary defect in the electroretinogram, indicating retinal dysfunction.
The identified mouse models are available without restriction to researchers.

Conclusions:

The TVRM program successfully generated and identified new mouse models relevant to vision research.
These models, specifically for Grm1, Grk1, and Lrit3, offer valuable resources for studying retinal development, function, and disease.
The unrestricted availability of these models will facilitate further research in the vision science community.