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Audiograms, gap detection thresholds, and frequency difference limens in cannabinoid receptor 1 knockout mice.
Katrina L Toal1, Kelly E Radziwon1, David P Holfoth1
1Department of Psychology, University at Buffalo SUNY, Buffalo, NY 14260, USA.
Hearing Research
|October 3, 2015
Summary
The cannabinoid receptor 1 (CB1R) plays a role in auditory processing. CB1R knockout mice showed hearing deficits at high frequencies but improved gap detection, suggesting its involvement in hearing.
Area of Science:
- Neuroscience
- Auditory Science
- Pharmacology
Background:
- Cannabinoid receptor 1 (CB1R) is present in the auditory pathway.
- The specific function of CB1R in hearing remains largely unknown.
Purpose of the Study:
- To investigate the role of CB1R in auditory processing.
- To compare hearing abilities between CB1R knockout mice and wild-type mice.
Main Methods:
- Utilized operant conditioning and the Method of Constant Stimuli.
- Measured audiograms, gap detection thresholds, and frequency difference limens.
- Employed trained mice using standardized methods and stimuli.
Main Results:
- CB1R knockout mice exhibited hearing deficits above 8 kHz.
- CB1R knockouts demonstrated enhanced gap detection in low-pass noisebursts.
- No significant differences were observed in frequency discrimination abilities.
Conclusions:
- CB1R is implicated in auditory processing.
- Findings provide a foundation for future physiological investigations into CB1R's auditory functions.
