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Related Experiment Video

Updated: Apr 1, 2026

Use of a Central Venous Line for Fluids, Drugs and Nutrient Administration in a Mouse Model of Critical Illness
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Nutritional Status and Mortality in the Critically Ill.

Kris M Mogensen1, Malcolm K Robinson, Jonathan D Casey

  • 11Department of Nutrition, Brigham and Women's Hospital, Boston, Massachusetts. 2Department of Surgery, Brigham and Women's Hospital, Boston, Massachusetts. 3Department of Medicine, Brigham and Women's Hospital, Boston, Massachusetts. 4Harvard Medical School, Boston, Massachusetts. 5Department of Medicine, Okinawa Hokubu Prefectural Hospital, Okinawa, Japan. 6Department of Medicine, The Nathan E. Hellman Memorial Laboratory, Renal Division, Brigham and Women's Hospital.

Critical Care Medicine
|October 3, 2015
PubMed
Summary

Critically ill patients with malnutrition face higher mortality risks. Protein-energy malnutrition significantly increases 30-day mortality, highlighting the importance of nutritional status in critical care outcomes.

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Area of Science:

  • Critical Care Medicine
  • Nutritional Science
  • Epidemiology

Background:

  • The relationship between nutritional status and mortality in critically ill patients remains incompletely understood.
  • Existing literature lacks clarity on how malnutrition impacts outcomes in intensive care unit (ICU) settings.

Purpose of the Study:

  • To investigate the association between nutritional status and mortality in a large cohort of critically ill adults.
  • To determine if malnutrition is a significant predictor of mortality in ICU patients.

Main Methods:

  • Retrospective observational study conducted at a single academic medical center.
  • Analysis of 6,518 adult patients admitted to medical and surgical ICUs between 2004 and 2011.
  • Nutritional status categorized as nonspecific malnutrition, protein-energy malnutrition, or well-nourished, assessed via comprehensive evaluations; mortality assessed using logistic regression and propensity score matching.

Main Results:

  • Nonspecific malnutrition was identified in 56% of patients, protein-energy malnutrition in 12%, and 32% were well-nourished.
  • Patients with nonspecific malnutrition had a 1.17-fold increased odds of 30-day mortality, while those with protein-energy malnutrition had a 2.10-fold increased odds compared to well-nourished patients.
  • Propensity score matching confirmed a two-fold greater adjusted odds of 30-day mortality for patients with protein-energy malnutrition.

Conclusions:

  • A significant association exists between nutritional status and mortality in critically ill adult patients.
  • Malnutrition, particularly protein-energy malnutrition, is a strong predictor of increased 30-day mortality in the ICU.
  • These findings underscore the critical role of nutritional assessment and intervention in improving outcomes for critically ill patients.