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Related Experiment Video

Updated: Apr 1, 2026

Experimental Demyelination and Remyelination of Murine Spinal Cord by Focal Injection of Lysolecithin

Experimental Demyelination and Remyelination of Murine Spinal Cord by Focal Injection of Lysolecithin

Published on: March 26, 2015

Contralateral recurrence of tumefactive demyelination.

Mohammed Nazir Khan¹, Mihail Guranda², Marco Essig³

¹Department of Radiology, University of Manitoba, Winnipeg, Canada nazirkhanmd@gmail.com.

The Neuroradiology Journal

|October 3, 2015

Summary

Tumefactive demyelination involves large brain lesions that can mimic cancer. This case report details a patient experiencing a recurrent tumefactive lesion two years after initial recovery, highlighting the unpredictable nature of this condition.

Keywords:

MRI Tumefactive demyelination brain contralateral multiple sclerosis neuroinflammation recurrence tumefactive multiple sclerosis

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Area of Science:

Neuroscience
Neurology
Radiology

Background:

Tumefactive demyelination presents as large focal brain lesions, often clinically and radiologically mimicking brain tumors.
While some cases are monophasic, recurrent tumefactive lesions can occur, sometimes preceding a diagnosis of multiple sclerosis.

Observation:

This case report describes a patient with a history of tumefactive demyelination.
The patient presented two years after initial recovery with a new tumefactive lesion in the contralateral hemisphere.

Findings:

The recurrence of tumefactive demyelination, even after apparent recovery, is possible.
The contralateral location of the recurrent lesion suggests unpredictable disease patterns.

Implications:

Further research is needed to understand the patterns and prognostic significance of recurrent tumefactive lesions.
Accurate diagnosis and long-term monitoring are crucial for patients with tumefactive demyelination due to potential recurrence and association with multiple sclerosis.