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Updated: Apr 1, 2026

Using a Murine Model of Psychosocial Stress in Pregnancy as a Translationally Relevant Paradigm for Psychiatric Disorders in Mothers and Infants
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SSRI use during pregnancy.

Heather Tran1, Adelaide S Robb1

  • 1Division of Psychology & Behavioral Health, Children's National Health Systems, 111 Michigan Ave, NW Washington, DC 20010.

Seminars in Perinatology
|October 3, 2015
PubMed
Summary

This review covers major depression (MDD) during and after pregnancy, focusing on Serotonin Selective Reuptake Inhibitors (SSRIs) use. It summarizes current knowledge on treating perinatal depression with SSRIs during pregnancy and breastfeeding.

Area of Science:

  • Perinatal mental health
  • Pharmacology in pregnancy
  • Reproductive psychiatry

Background:

  • Major Depressive Disorder (MDD) is a significant concern during the perinatal period.
  • Treatment decisions for MDD during pregnancy and breastfeeding require careful consideration of risks and benefits.

Purpose of the Study:

  • To review the current understanding of MDD in pregnant and postpartum individuals.
  • To discuss the safety and efficacy of Serotonin Selective Reuptake Inhibitors (SSRIs) for treating MDD during pregnancy and breastfeeding.

Main Methods:

  • Literature review of studies on perinatal MDD and SSRI use.
  • Synthesis of evidence presented at a Society of Maternal and Fetal Medicine conference.

Main Results:

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  • SSRIs are frequently considered for treating MDD during pregnancy and breastfeeding.
  • Evidence on the specific risks and benefits of different SSRIs in this population is continually evolving.

Conclusions:

  • Managing MDD during pregnancy and breastfeeding requires individualized treatment plans.
  • Ongoing research is crucial for informing clinical practice regarding SSRI use in perinatal populations.