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The NESH/Abi-3-based WAVE2 complex is functionally distinct from the Abi-1-based WAVE2 complex

Saki Sekino1, Yuriko Kashiwagi2, Hitoshi Kanazawa3

  • 1School of Life Sciences, Tokyo University of Pharmacy and Life Sciences, Hachioji, Tokyo, 192-0392, Japan. pupa72040320@yahoo.co.jp.

Cell Communication and Signaling : CCS
|October 3, 2015
PubMed
Summary

The NESH/Abi-3 protein forms a WAVE2 complex distinct from Abi-1, impairing lamellipodial protrusions but promoting invadopodia formation in specific conditions. This highlights functional differences in Abl interactor (Abi) family proteins.

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