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Saturation pulse design for quantitative myocardial T1 mapping.

Kelvin Chow1, Peter Kellman2, Bruce S Spottiswoode3

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Journal of Cardiovascular Magnetic Resonance : Official Journal of the Society for Cardiovascular Magnetic Resonance
|October 3, 2015
PubMed
Summary
This summary is machine-generated.

Optimized saturation pulses for quantitative T1 mapping achieve less than 1% residual magnetization, improving accuracy in MRI. These advanced pulses reduce errors in T1 measurements across various field strengths and inhomogeneities.

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Area of Science:

  • Magnetic Resonance Imaging (MRI)
  • Quantitative Imaging
  • Pulse Sequence Design

Background:

  • Quantitative saturation-recovery T1 mapping offers improved accuracy over MOLLI but requires high-performance saturation pulses.
  • Systematic errors in T1 mapping can be reduced by optimizing saturation pulses for B0 and B1 inhomogeneity.

Purpose of the Study:

  • To optimize adiabatic and pulse train saturation pulses for quantitative T1 mapping.
  • Achieve <1% absolute residual longitudinal magnetization (|MZ/M0|) under realistic B0 and B1 inhomogeneity conditions at 1.5T and 3T.

Main Methods:

  • Optimized adiabatic BIR4-90 pulse parameters for 1.5T field inhomogeneity.
  • Optimized flip angles for 3-6 pulse trains at 1.5T and 3T, considering T1 values and field variations.
  • Simulated and experimentally measured residual MZ/M0 using phantoms and in-vivo studies with SAturation recovery single-SHot Acquisition (SASHA).

Main Results:

  • Optimized BIR4-90 reduced maximum residual |MZ/M0| by 5.8x (<1%) compared to a reference.
  • Optimized 3-pulse train achieved <1% residual |MZ/M0| at 1.5T (vs. 11.3% for standard 90°-90°-90°).
  • A 6-pulse train met the <1% target across wider 3T ranges and showed more uniform saturation and spatially homogeneous T1 maps in human and animal studies.

Conclusions:

  • Optimized adiabatic and pulse train saturation pulses successfully achieved <1% residual |MZ/M0| at 1.5T and 3T.
  • These optimized pulses enhance accuracy in quantitative saturation recovery T1 imaging.