Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Diencephalon: Hypothalamus and Coordination01:23

Diencephalon: Hypothalamus and Coordination

5.2K
The hypothalamus is a small yet highly complex and essential brain region that plays a crucial role in regulating various bodily functions. Anatomically, it is located at the base of the brain, just above the brainstem and below the thalamus, forming part of the limbic system.
The hypothalamus interacts with other brain regions, including the pituitary gland, through a direct physical connection called the hypothalamic-pituitary axis. The hypothalamus receives somatic and visceral inputs and...
5.2K
Brainstem: Control Centers of Medulla01:21

Brainstem: Control Centers of Medulla

5.4K
The medulla oblongata is a crucial part of the brainstem responsible for controlling various autonomic and involuntary functions. It contains several nuclei, including the olivary, cuneate, gracile, and solitary nuclei.
Olivary Nucleus
The olivary nucleus, or inferior olivary nucleus, is located within the ventrolateral part of the medulla oblongata. It is primarily involved in motor coordination and motor learning. The olivary nucleus receives input from the spinal cord, cerebellum, and motor...
5.4K
Regulation of Food Intake01:30

Regulation of Food Intake

3.2K
Short-term regulation of food intake primarily involves neural signals from the gastrointestinal (GI) tract, blood nutrient levels, and GI tract hormones. Communication between the gut and brain via vagal nerve fibers plays a significant role in evaluating the contents of the gut. Clinical studies have shown that protein ingestion produces a more prolonged response in these nerve fibers compared to an equivalent amount of glucose. Additionally, the activation of stretch receptors caused by GI...
3.2K
Diencephalon: Thalamus and Information Relay01:27

Diencephalon: Thalamus and Information Relay

5.5K
The thalamus, often called “the gateway to the cerebral cortex,” is vital in processing and directing sensory and motor signals throughout the brain. Almost all inputs destined for the cerebral cortex, except for olfactory signals, are relayed through the thalamus. The thalamus is  a sophisticated relay station, channeling information from various brain regions to the cerebral cortex, as well as a filter, prioritizing certain signals over others based on current physiological...
5.5K
Neural Regulation01:37

Neural Regulation

44.9K
Digestion begins with a cephalic phase that prepares the digestive system to receive food. When our brain processes visual or olfactory information about food, it triggers impulses in the cranial nerves innervating the salivary glands and stomach to prepare for food.
44.9K
Self-Regulation01:25

Self-Regulation

323
Self-regulation, also known as self-control, encompasses a range of cognitive and behavioral processes that allow individuals to adjust their internal states and outward actions to align with socially acceptable norms and long-term goals. It plays a fundamental role in adaptive functioning, from resisting impulsive behaviors to persisting through challenging tasks. While its benefits are widely recognized, self-regulation is not limitless. Muraven and Baumeister's theory posits that...
323

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Machine Diagnostics and Machine Phenotyping of Migraine: A HUNT Study.

Neurology·2026
Same author

Cortical-Subthalamic Interplay During Eyes-Open and Eyes-Closed Resting States in Parkinson's Disease Patients.

International journal of neural systems·2026
Same author

Impaired P3 encoding and frontoparietal network imbalance characterize visual working memory deficits in newly diagnosed patients with multiple sclerosis: multimodal evidence from electrophysiology and structural neuroimaging.

NeuroImage·2026
Same author

Topological modelling of urban air pollution and cognition.

npj digital public health·2026
Same author

Forecasting migraine with time-series machine learning from mobile health data.

The journal of headache and pain·2026
Same author

Early versus delayed anticoagulation in acute ischemic stroke with atrial fibrillation according to infarct volume and location: A prespecified subgroup analysis of the OPTIMAS randomized controlled trial.

International journal of stroke : official journal of the International Stroke Society·2026
Same journal

Fus-depleted oligodendrocytes reduce neuronal damage and Alzheimer's disease progression in the AppNL-G-F mouse.

Brain : a journal of neurology·2026
Same journal

Cervical lymph node biomarkers in neurodegeneration.

Brain : a journal of neurology·2026
Same journal

Lower motor neuron disorders: time for a closer look.

Brain : a journal of neurology·2026
Same journal

Reply: Cervical lymph node biomarkers in neurodegeneration.

Brain : a journal of neurology·2026
Same journal

Propionic acid and neurofilament light chain in multiple sclerosis.

Brain : a journal of neurology·2026
Same journal

Propionic acid in multiple sclerosis: a phase 2b, double-blind, randomized placebo-controlled trial.

Brain : a journal of neurology·2026
See all related articles

Related Experiment Video

Updated: Apr 1, 2026

A Conflict Model of Reward-seeking Behavior in Male Rats
06:11

A Conflict Model of Reward-seeking Behavior in Male Rats

Published on: February 20, 2019

8.0K

Dynamic risk control by human nucleus accumbens.

Parashkev Nachev1, Fernando Lopez-Sosa2, Javier Jesus Gonzalez-Rosa2

  • 11 Institute of Neurology, UCL, London, UK p.nachev@ucl.ac.uk bryan.strange@upm.es.

Brain : a Journal of Neurology
|October 3, 2015
PubMed
Summary
This summary is machine-generated.

Deep brain stimulation of the nucleus accumbens dynamically altered risky decision-making in patients. This research establishes a critical role for the nucleus accumbens in real-time risk control.

Keywords:
decision-makingnucleus accumbensrewardrisksubcortical electrical stimulation

More Related Videos

Identification of Dopamine D1-Alpha Receptor Within Rodent Nucleus Accumbens by an Innovative RNA In Situ Detection Technology
07:25

Identification of Dopamine D1-Alpha Receptor Within Rodent Nucleus Accumbens by an Innovative RNA In Situ Detection Technology

Published on: March 27, 2018

9.1K
Non-invasive Strategies for Chronic Manipulation of DREADD-controlled Neuronal Activity
08:28

Non-invasive Strategies for Chronic Manipulation of DREADD-controlled Neuronal Activity

Published on: August 25, 2019

14.7K

Related Experiment Videos

Last Updated: Apr 1, 2026

A Conflict Model of Reward-seeking Behavior in Male Rats
06:11

A Conflict Model of Reward-seeking Behavior in Male Rats

Published on: February 20, 2019

8.0K
Identification of Dopamine D1-Alpha Receptor Within Rodent Nucleus Accumbens by an Innovative RNA In Situ Detection Technology
07:25

Identification of Dopamine D1-Alpha Receptor Within Rodent Nucleus Accumbens by an Innovative RNA In Situ Detection Technology

Published on: March 27, 2018

9.1K
Non-invasive Strategies for Chronic Manipulation of DREADD-controlled Neuronal Activity
08:28

Non-invasive Strategies for Chronic Manipulation of DREADD-controlled Neuronal Activity

Published on: August 25, 2019

14.7K

Area of Science:

  • Neuroscience
  • Decision Science
  • Psychiatry

Background:

  • Real-world reward decisions involve balancing risk and value.
  • The nucleus accumbens is implicated in reward processing, but its causal role in human behavior is unclear.

Purpose of the Study:

  • To investigate the nucleus accumbens' role in human risk-taking behavior using interventional methods.
  • To probe the behavioral consequences of focal neural modulation in the nucleus accumbens.

Main Methods:

  • Combined a psychometric index of risky decision-making with transient electrical modulation of the nucleus accumbens.
  • Utilized therapeutic deep brain stimulation in four patients with treatment-resistant psychiatric disease.

Main Results:

  • Phasic electrical stimulation of the nucleus accumbens dynamically altered risk behavior.
  • Stimulation transiently shifted decision-making towards riskier choices, only during the period of stimulation.

Conclusions:

  • Established a critical, on-line role for the human nucleus accumbens in dynamic risk control.
  • Demonstrated that modulating the nucleus accumbens can acutely influence risk-reward assessments.