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Adalimumab for refractory pulmonary sarcoidosis
P A Minnis1,2, M Poland3, M P Keane3,4
1School of Medicine and Medical Science, College of Life Sciences, UCD Conway Institute of Biomolecular and Biomedical Research, University College Dublin, Belfield, Dublin, Ireland. paul.minnis@ucd.ie.
Adalimumab treatment improved symptoms and lung function in patients with refractory pulmonary sarcoidosis. This suggests Adalimumab is a viable option for managing severe sarcoidosis cases.
Area of Science:
- Pulmonology
- Immunology
- Rheumatology
Background:
- Sarcoidosis has a high prevalence in Ireland.
- Anti-TNF therapy for sarcoidosis is typically reserved for cases with poor response to corticosteroids.
Observation:
- This study reports the use of Adalimumab in patients with refractory pulmonary sarcoidosis.
- The experience with Adalimumab in this patient cohort is discussed.
Findings:
- All patients experienced symptomatic improvement with Adalimumab treatment.
- Stabilization or improvement in Diffusing capacity of the lungs for carbon monoxide (DLCO sb) was observed.
- Pulmonary function test improvements correlated with radiological stage and disease duration.
Implications:
- Adalimumab shows promise in managing refractory pulmonary sarcoidosis.
- Treatment implications for sarcoidosis patients with sub-optimal corticosteroid response are discussed.
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