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Adalimumab for refractory pulmonary sarcoidosis
P A Minnis1,2, M Poland3, M P Keane3,4
1School of Medicine and Medical Science, College of Life Sciences, UCD Conway Institute of Biomolecular and Biomedical Research, University College Dublin, Belfield, Dublin, Ireland. paul.minnis@ucd.ie.
Background:
Ireland has one of the highest prevalence of sarcoidosis globally. Currently anti-TNF treatment in sarcoidosis is considered on a case-by-case basis particularly in patients who have a sub-optimal response to corticosteroid therapy.
Aims:
We report our experience of Adalimumab in a series of refractory pulmonary sarcoidosis and discuss implications for treatment.
Conclusion:
Symptomatic improvement was found in all patients as well as stabilisation or improvement in DLCO sb. Improvements in pulmonary function tests correlated well to radiological stage and length of disease.
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