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Updated: Apr 1, 2026

Direct Drug Delivery to Kidney via the Renal Artery
Published on: April 17, 2021
Methylene blue treatment for resistant shock following renal transplantation
Eli Hershman1, Amir Hadash1, Ori Attias1
1Department of Pediatric Intensive Care, Ruth Rappaport Children's Hospital at Rambam Health Care Campus, Haifa, Israel.
Abstract:
We report a case of a 19-year-old female with a history of hyperoxaluria type 1 and renal failure. The patient presented for a second renal transplantation 17 years after her first combined liver and kidney transplantation. Postoperative shock was highly resistant to fluids and required massive pharmacologic hemodynamic support. Vasoplegic shock was the presumed diagnosis, and methylene blue was utilized as a rescue therapy, with a rapid hemodynamic response and no apparent side effects.
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