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Related Experiment Video

Updated: Apr 1, 2026

Four-Dimensional CT Analysis Using Sequential 3D-3D Registration

Four-Dimensional CT Analysis Using Sequential 3D-3D Registration

Published on: November 23, 2019

Technical Note: Simulation of 4DCT tumor motion measurement errors.

Tai H Dou¹, David H Thomas¹, Dylan O'Connell¹

¹Department of Radiation Oncology, University of California Los Angeles, Los Angeles, California 90095.

Medical Physics

|October 3, 2015

Summary

This summary is machine-generated.

Commercial 4DCT protocols can significantly miscalculate tumor breathing motion, leading to substantial overestimations or underestimations. These findings highlight potential inaccuracies in 4D CT imaging for radiation therapy planning.

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Last Updated: Apr 1, 2026

Four-Dimensional CT Analysis Using Sequential 3D-3D Registration

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Published on: November 23, 2019

Dynamic Lung Tumor Tracking for Stereotactic Ablative Body Radiation Therapy

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Construction of a Preclinical Multimodality Phantom Using Tissue-mimicking Materials for Quality Assurance in Tumor Size Measurement

Construction of a Preclinical Multimodality Phantom Using Tissue-mimicking Materials for Quality Assurance in Tumor Size Measurement

Published on: July 29, 2013

Area of Science:

Medical Imaging
Radiotherapy Physics

Background:

Four-dimensional computed tomography (4DCT) is crucial for accurate tumor targeting in radiation therapy.
Tumor motion due to respiration can introduce significant errors in treatment planning if not precisely measured.

Purpose of the Study:

To evaluate the accuracy of commercial 4DCT protocols in measuring tumor breathing motion.
To quantify the extent to which 4DCT overestimates or underestimates tumor motion.

Main Methods:

1D simulations modeled a 16-slice CT scanner and tumors moving with breathing surrogates from 50 patients.
Tumor motion was simulated based on breathing amplitudes and CT scanner pitch.
Measured tumor motion was calculated by analyzing overlapping CT slices and tumor positions.

Main Results:

Simulations revealed potential for significant motion measurement errors with commercial 4DCT protocols.
Using a pitch of 0.06, 30% of patients showed overestimations of 47% and 30% showed underestimations of 36%.
With a pitch of 0.1, overestimations reached 37% and underestimations reached 61%.

Conclusions:

Commercial low-pitch helical 4DCT protocols are prone to substantial errors in tumor motion measurement.
Both overestimation and underestimation of tumor motion can occur, impacting treatment accuracy.
Further investigation into optimizing 4DCT acquisition parameters is warranted.