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Updated: Apr 1, 2026

Fast and Accurate Exhaled Breath Ammonia Measurement
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A fully integrated standalone portable cavity ringdown breath acetone analyzer.

Meixiu Sun1, Chenyu Jiang1, Zhiyong Gong1

  • 1Laser Medicine Laboratory, Institute of Biomedical Engineering, Chinese Academy of Medical Sciences and Peking Union Medical College, Tianjin 300192, China.

The Review of Scientific Instruments
|October 3, 2015
PubMed
Summary

A new portable breath analyzer uses cavity ringdown spectroscopy for real-time acetone measurements. This instrument enables high-throughput, noninvasive breath analysis for disease screening and metabolic monitoring.

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Area of Science:

  • Analytical Chemistry
  • Biomedical Engineering
  • Spectroscopy

Background:

  • Breath analysis offers a noninvasive method for disease diagnosis and metabolic monitoring.
  • A key challenge is establishing quantitative links between breath biomarkers and clinical parameters.
  • Real-time, high-throughput instruments are needed for large-scale clinical breath analysis.

Purpose of the Study:

  • To develop a fully integrated, standalone, portable analyzer for near-real-time, online breath acetone measurements.
  • To validate the performance of the new analyzer against certified gas chromatography-mass spectrometry.
  • To demonstrate the utility of the analyzer in measuring breath acetone in a human cohort.

Main Methods:

  • Cavity ringdown spectroscopy (CRDS) technique was employed for breath analysis.
  • A portable, integrated analyzer was designed and constructed.
  • Performance validation was conducted using certified gas chromatography-mass spectrometry (GC-MS).

Main Results:

  • The portable analyzer achieved high sensitivity (57 ppb) and high data throughput (1 Hz).
  • Measurements were validated against GC-MS, demonstrating reliability for online breath acetone analysis.
  • The instrument was successfully used to measure breath acetone in 119 human subjects.

Conclusions:

  • The developed portable analyzer is a valuable tool for large-scale, online breath acetone analysis.
  • The instrument platform can be adapted for the study of other breath biomarkers.
  • This technology advances noninvasive diagnostic and monitoring capabilities.