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Metaboreflex activity in multiple sclerosis patients.

Elisabetta Marongiu1, Sergio Olla1, Sara Magnani1

  • 1Sports Physiology Lab, Department of Medical Sciences, University of Cagliari, Via Porcell 4, 09124, Cagliari, Italy.

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Multiple sclerosis patients exhibit impaired stroke volume during exercise metaboreflex activation, despite maintaining blood pressure through vasoconstriction, likely due to deconditioning.

Keywords:
Autonomic systemCardiovascular regulationSystemic vascular resistance

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Area of Science:

  • Cardiovascular Physiology
  • Exercise Science
  • Neuroimmunology

Background:

  • The muscle metaboreflex is crucial for normal exercise hemodynamics.
  • Multiple sclerosis (MS) is associated with autonomic dysfunction and impaired cardiovascular regulation during exercise.
  • The metaboreflex response in MS patients remains understudied.

Purpose of the Study:

  • To investigate the hemodynamic response to metaboreflex activation in MS patients compared to controls.
  • To assess differences in cardiovascular regulation during exercise between MS patients and healthy individuals.

Main Methods:

  • Utilized the post-exercise muscle ischemia (PEMI) method to activate the metaboreflex.
  • Employed a control exercise recovery (CER) test for comparison.
  • Measured hemodynamic responses, including mean blood pressure and stroke volume, using impedance cardiography.

Main Results:

  • MS patients maintained mean blood pressure similarly to controls but with significantly higher systemic vascular resistance.
  • The MS group demonstrated an impaired ability to increase stroke volume compared to the control group.
  • This suggests a compensatory mechanism involving vasoconstriction to maintain blood pressure.

Conclusions:

  • MS patients exhibit an impaired stroke volume response to low-level metaboreflex activation.
  • Sustained blood pressure in MS patients during metaboreflex is achieved via increased vasoconstriction.
  • Chronic physical deconditioning is a likely contributing factor to these observed cardiovascular impairments in MS.