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Complete Genome Sequence of Citrobacter freundii Myophage Merlin

Kayla C LeSage1, Emily C Hargrove1, Jesse L Cahill1

  • 1Center for Phage Technology, Texas A&M University, College Station, Texas, USA.

Genome Announcements
|October 3, 2015
PubMed

Insights

The complete genome of bacteriophage Merlin, a T4-like myophage, has been sequenced. This myophage infects Citrobacter freundii, an opportunistic pathogen causing nosocomial infections.

Area of Science:

  • Microbiology
  • Genomics
  • Virology

Background:

  • Citrobacter freundii is an opportunistic pathogen frequently causing nosocomial infections.
  • Enterobacteriaceae family members are significant in human health and disease.
  • Bacteriophages are viruses that infect bacteria and are potential tools in combating bacterial infections.

Purpose of the Study:

  • To announce the complete genome sequence of bacteriophage Merlin.
  • To describe the genomic features of bacteriophage Merlin.
  • To provide a genomic resource for studying T4-like myophages and their hosts.

Main Methods:

  • Whole-genome sequencing of bacteriophage Merlin.
  • Bioinformatic analysis of the Merlin genome.
  • Comparative genomics with related T4-like myophages.

Main Results:

  • The complete genome of bacteriophage Merlin has been determined.
  • Genomic analysis revealed specific features of Merlin, including gene content and organization.
  • Merlin shares characteristics with other T4-like myophages, suggesting a common evolutionary history.

Conclusions:

  • The availability of the Merlin genome provides valuable data for understanding myophage biology.
  • This genomic information can aid in the development of phage-based therapeutic strategies against Citrobacter freundii infections.
  • Bacteriophage Merlin represents a significant addition to the genomic resources for Enterobacteriaceae-infecting phages.

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