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Updated: Apr 1, 2026

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Alignment and fixation in total knee arthroplasty: changing paradigms
S Oussedik1, M P Abdel2, M B Cross3
1University College London Hospitals, 235 Euston Road, London NW1 2BU, UK.
Abstract:
Many aspects of total knee arthroplasty have changed since its inception. Modern prosthetic design, better fixation techniques, improved polyethylene wear characteristics and rehabilitation, have all contributed to a large change in revision rates. Arthroplasty patients now expect longevity of their prostheses and demand functional improvement to match. This has led to a re-examination of the long-held belief that mechanical alignment is instrumental to a successful outcome and a focus on restoring healthy joint kinematics. A combination of kinematic restoration and uncemented, adaptable fixation may hold the key to future advances.
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