Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Improving Translational Accuracy02:07

Improving Translational Accuracy

15.5K
Base complementarity between the three base pairs of mRNA codon and the tRNA anticodon is not a failsafe mechanism. Inaccuracies can range from a single mismatch to no correct base pairing at all. The free energy difference between the correct and nearly correct base pairs can be as small as 3 kcal/ mol. With complementarity being the only proofreading step, the estimated error frequency would be one wrong amino acid in every 100 amino acids incorporated. However, error frequencies observed in...
15.5K
Improving Translational Accuracy02:07

Improving Translational Accuracy

3.8K
3.8K
Genomics02:02

Genomics

41.8K
Genomics is the science of genomes: it is the study of all the genetic material of an organism. In humans, the genome consists of information carried in 23 pairs of chromosomes in the nucleus, as well as mitochondrial DNA. In genomics, both coding and non-coding DNA is sequenced and analyzed. Genomics allows a better understanding of all living things, their evolution, and their diversity. It has a myriad of uses: for example, to build phylogenetic trees, to improve productivity and...
41.8K
Translation01:31

Translation

22.2K
Translation is the process of synthesizing proteins from the genetic information carried by messenger RNA (mRNA). Following transcription, it constitutes the final step in the expression of genes. This process is carried out by ribosomes, complexes of protein and specialized RNA molecules. Ribosomes, transfer RNA (tRNA), and other proteins produce a chain of amino acids—the polypeptide—as the end product of translation.
Translation Produces the Building Blocks of Life
Proteins are...
22.2K
Proteomics01:33

Proteomics

10.2K
A proteome is the entire set of proteins that a cell type produces. We can study proteomes using the knowledge of genomes because genes code for mRNAs, and the mRNAs encode proteins. Although mRNA analysis is a step in the right direction, not all mRNAs are translated into proteins.
Proteomics is the study of proteomes' function. It involves the large-scale systematic study of the proteome to denote the protein complement expressed by a genome. Scientist Mark Wilkins coined the term...
10.2K
Clinical Trials: Overview01:11

Clinical Trials: Overview

5.4K
Clinical development focuses on how the drug will interact with the human body and encompasses four key phases of clinical trials, each serving a specific purpose in assessing the safety and effectiveness of new drugs. These phases overlap and build upon one another. Phase I involves a small group of healthy volunteers (typically 20-80 individuals) or, in cases where significant toxicity is expected, patients with the targeted disease, such as cancer or AIDS. The volunteers are tested for...
5.4K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Colocalization of eQTLs With Type 2 Diabetes and Glycemic Traits Using Whole-Genome Sequences in Diverse Populations From the NHLBI Trans-Omics in Precision Medicine (TOPMed) Program.

Diabetes·2026
Same author

Rare coding variant architecture and gene discovery from 130,000 sequenced cases of atrial fibrillation.

Research square·2026
Same author

Understanding adolescents' perspectives on suicide risk screening in primary care: Implications and insights for implementation and practice.

PLOS mental health·2026
Same author

Multi-scale data improves performance of machine learning model for long COVID identification.

Communications medicine·2026
Same author

Governing real-world health data as a public utility.

Science (New York, N.Y.)·2026
Same author

Speaker Role Identification in Clinical Conversations.

Pacific Symposium on Biocomputing. Pacific Symposium on Biocomputing·2026

Related Experiment Video

Updated: Apr 1, 2026

Microfluidic Co-Culture Models for Dissecting the Immune Response in in vitro Tumor Microenvironments
07:46

Microfluidic Co-Culture Models for Dissecting the Immune Response in in vitro Tumor Microenvironments

Published on: April 30, 2021

5.7K

A conceptual model for translating omic data into clinical action.

Timothy M Herr1, Suzette J Bielinski2, Erwin Bottinger3

  • 1Department of Preventive Medicine, Division of Health and Biomedical Informatics, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA.

Journal of Pathology Informatics
|October 3, 2015
PubMed
Summary

The "omic funnel" model translates complex genomic and proteomic data into actionable insights for precision medicine. This framework aids researchers and clinicians in moving omic discoveries from the lab to patient care effectively.

Keywords:
Genomic medicinepersonalized health careprecision medicine

More Related Videos

Author Spotlight: Impact of Intergenic Interactions on Disease-Identifying Dark Biomarkers
03:37

Author Spotlight: Impact of Intergenic Interactions on Disease-Identifying Dark Biomarkers

Published on: March 1, 2024

1.5K
A Metadata Extraction Approach for Clinical Case Reports to Enable Advanced Understanding of Biomedical Concepts
07:50

A Metadata Extraction Approach for Clinical Case Reports to Enable Advanced Understanding of Biomedical Concepts

Published on: September 20, 2018

16.6K

Related Experiment Videos

Last Updated: Apr 1, 2026

Microfluidic Co-Culture Models for Dissecting the Immune Response in in vitro Tumor Microenvironments
07:46

Microfluidic Co-Culture Models for Dissecting the Immune Response in in vitro Tumor Microenvironments

Published on: April 30, 2021

5.7K
Author Spotlight: Impact of Intergenic Interactions on Disease-Identifying Dark Biomarkers
03:37

Author Spotlight: Impact of Intergenic Interactions on Disease-Identifying Dark Biomarkers

Published on: March 1, 2024

1.5K
A Metadata Extraction Approach for Clinical Case Reports to Enable Advanced Understanding of Biomedical Concepts
07:50

A Metadata Extraction Approach for Clinical Case Reports to Enable Advanced Understanding of Biomedical Concepts

Published on: September 20, 2018

16.6K

Area of Science:

  • Bioinformatics
  • Genomics
  • Proteomics
  • Epigenomics
  • Computational Biology

Background:

  • Advancements in omics technologies generate vast datasets (genomic, proteomic, epigenomic).
  • The complexity and volume of omics data exceed human cognitive limits for clinical application.
  • Translating omics data into patient care is crucial for advancing precision medicine.

Purpose of the Study:

  • To present a conceptual model, the "omic funnel," for applying omics data in clinical settings.
  • To provide a structured approach for translating omics data from research (bench) to patient care (bedside).
  • To facilitate the development of software for widespread precision medicine implementation.

Main Methods:

  • Conceptual modeling based on the Data-Information-Knowledge-Wisdom (DIKW) pyramid.
  • Defining discrete steps and needs for each layer of the omic funnel.
  • Outlining a framework for informaticians, researchers, and clinicians.

Main Results:

  • The omic funnel model provides a clear pathway for omics data translation.
  • It addresses the challenge of cognitive overload with large omics datasets.
  • The model supports the development of modular and interoperable software solutions.

Conclusions:

  • The omic funnel offers a systematic approach to integrate omics data into clinical practice.
  • This framework is essential for realizing the full potential of precision medicine.
  • Standardized translation processes can accelerate the adoption of personalized medicine.