Related Experiment Video
Updated: Apr 1, 2026
13:00
Measuring Attention and Visual Processing Speed by Model-based Analysis of Temporal-order Judgments
Published on: January 23, 2017
10.4K
The two faces of TOE-2
1Molecular and Cell Biology; University of California ; Berkeley, CA USA ; Present address: Department of Biochemistry; University of Utah ; Salt Lake City, UT USA.
Worm
|October 3, 2015
Summary
Researchers found TOE-2 protein has two roles in programmed cell death (apoptosis) during C. elegans neuroblast division. This study explores TOE-2
Area of Science:
- Cell biology
- Developmental biology
- Genetics
Background:
- The C. elegans Q lineage provides a model for studying asymmetric cell division and apoptosis.
- Neuroblasts Q.a and Q.p divide asymmetrically, producing neurons and cells destined for apoptosis.
- These neuroblasts utilize distinct mechanisms for asymmetric division.
Purpose of the Study:
- To investigate the roles of TOE-2, a target of MPK-1 (ERK ortholog), in neuroblast apoptosis.
- To elucidate the molecular mechanisms underlying TOE-2's function in promoting apoptosis.
- To explore potential interactions and pathways involving TOE-2.
Main Methods:
- Analysis of C. elegans Q lineage development.
- Investigation of protein interactions and cellular localization of TOE-2.
- Exploration of potential links to signaling pathways like Wnt.
Main Results:
- TOE-2 plays two distinct roles in promoting apoptosis during Q lineage neuroblast divisions.
- Evidence suggests TOE-2's involvement in both cytoplasmic and potentially nuclear functions.
- A potential connection between TOE-2 and the Wnt signaling pathway is proposed.
Conclusions:
- TOE-2 is a key regulator of apoptosis in C. elegans neuroblast asymmetric cell divisions.
- Understanding TOE-2's mechanisms can shed light on conserved pathways controlling cell fate.
- Further research is warranted to fully characterize TOE-2's interactions and functions.
Related Concept Videos
01:19Thomson's e/m Experiment
7.7K
In a beam of charged particles created by a heated cathode, the particles move at different speeds. However, many applications need a beam with uniform particle speeds. An arrangement known as a velocity selector uses electric and magnetic fields to pick particles with a particular speed from the beam.
A particle with charge q, speed v, and mass m enters an area from the top, where the magnetic and electric fields are perpendicular both to the particle's motion and to one another. The magnetic...
A particle with charge q, speed v, and mass m enters an area from the top, where the magnetic and electric fields are perpendicular both to the particle's motion and to one another. The magnetic...
7.7K
01:10Torque
23.5K
Torque is an important quantity for describing the dynamics of a rotating rigid body. We see the application of torque in many ways in the world, such as when pressing the accelerator in a car, which causes the engine to apply additional torque on the drivetrain. Here, we define torque and provide a framework to create an equation to calculate torque for a rigid body with fixed-axis rotation.
Torque can be considered as the rotational counterpart to force. Since forces change the translational...
Torque can be considered as the rotational counterpart to force. Since forces change the translational...
23.5K
01:26Orthogonal Trajectories
255
Orthogonal trajectories describe the geometric relationship between two families of curves that intersect each other at right angles. One illustrative case involves a family of parabolas that open sideways along the x-axis. These curves share a common shape but differ by a scaling parameter, resulting in a set of curves that all pass through the origin and widen at different rates.Determining Orthogonal TrajectoriesTo identify the orthogonal trajectories for these parabolas, the first step...
255
01:15Torque Free Motion
910
The torque-free motion refers to the movement of a rigid body in space when no external torques are acting upon it. This type of motion can be observed in environments where there are no external forces or frictions, like in outer space. For example, a rotation of Mars in space is a torque-free motion. Mars is an axisymmetric object, meaning it has an axis of symmetry along which it rotates, designated as the z-axis. The rotating frame of reference is defined such that the center of mass of...
910
01:06Thermodynamic Systems
9.2K
A thermodynamic system is a set of objects whose thermodynamic properties are of interest. The system is considered to be embedded in its surroundings or the environment. The system and its environment can exchange heat and do work on each other through a boundary that separates them. However, the immediate surroundings of the system interact with it directly and therefore have a much stronger influence on its behavior and properties.
Consider an example of tea boiling in a kettle. The...
Consider an example of tea boiling in a kettle. The...
9.2K
01:14The Second Law of Thermodynamics
7.2K
In the quest to identify a property that may reliably predict the spontaneity of a process, a promising candidate has been identified: entropy. Scientists refer to the measure of randomness or disorder within a system as entropy. High entropy means high disorder and low energy. To better understand entropy, think of a student’s bedroom. If no energy or work were put into it, the room would quickly become messy. It would exist in a very disordered state, one of high entropy. Energy must be...
7.2K