Urothelial Carcinoma Concomitant With Malakoplakia In Non-Functioning Nephrolithic Kidneys
Sezen Kocarslan1, Dilek Sen Dokumaci2, Emel Yigit Karakas3
1Department of Pathology
Folia Medica
|October 3, 2015
Summary
Malakoplakia and non-functioning kidneys pose significant health risks, increasing the likelihood of urothelial neoplasm. This case highlights urothelial carcinoma occurring with malakoplakia in such kidneys.
Area of Science:
- Nephrology
- Urology
- Oncology
Background:
- Malakoplakia is a rare condition characterized by the presence of Michaelis-Guttmann bodies.
- Non-functioning kidneys, often due to nephrolithiasis, present complex clinical challenges.
- Urothelial neoplasm represents a significant risk in patients with chronic kidney disease and inflammation.
Observation:
- A case of concomitant malakoplakia and urothelial carcinoma was observed.
- The condition occurred in non-functioning kidneys associated with nephrolithiasis.
- The patient presented with symptoms related to kidney dysfunction and potential malignancy.
Findings:
- Histopathological examination confirmed the presence of both malakoplakia and urothelial carcinoma.
- The non-functioning kidney provided a unique environment for the co-occurrence of these pathologies.
- The study details the specific characteristics of the observed urothelial carcinoma.
Implications:
- This case underscores the importance of considering malignancy in patients with non-functioning kidneys and malakoplakia.
- Early diagnosis and management are crucial for improving patient outcomes.
- Further research is needed to understand the pathogenetic link between malakoplakia, nephrolithiasis, and urothelial carcinoma.
More Related Videos
Related Concept Videos
01:26Urinary Tract Calculi II: Pathophysiology and Clinical Manifestations
698
Renal calculi, commonly termed kidney stones, are crystalline solid masses that form in the kidneys but can occur at any point within the urinary system, encompassing the kidneys, ureters, bladder, and urethra.The pathophysiology of renal stones involves several key factors: supersaturation of the urine with stone-forming constituents, changes in urine pH, a decrease in urine volume, and the presence of substances that promote or inhibit stone formation.Supersaturation of Urine: This is the...
698
01:28Urinary Tract Calculi I: Introduction
872
Renal calculi, or kidney stones, are solid deposits of minerals and salts formed inside the kidneys. In medical terminology, "calculus" refers to the stone itself, while "lithiasis" describes the process of stone formation. Depending on their location within the urinary system, these stones may be classified as either urolithiasis, when situated within the urinary tract, or nephrolithiasis, when located within the kidneys. Each term signifies the specific impact of the stone.Predisposition...
872
01:10Nephrons
9.0K
The kidneys are intricate organs with millions of working units known as nephrons. Each nephron features two major structures: the renal corpuscle, which facilitates blood plasma filtration, and the renal tubule, which handles the glomerular filtrate. Blood supply is directly linked to the nephrons. The renal corpuscle consists of the glomerulus, a capillary network, and the Bowman's capsule, a double-walled epithelial structure that encases the glomerulus. The filtering of blood plasma...
9.0K
01:30Urinary Tract Calculi III: Medical Management
325
The diagnosis of renal calculi involves several imaging techniques, including non-contrast CT scans and ultrasound. These methods help visualize kidney stones, assess their size and location, and detect possible obstructions. Additionally, Measuring urine pH is useful for diagnosing specific stone types, such as struvite (alkaline pH) and uric acid stones (acidic pH). Cystine stones are primarily linked to cystinuria, a genetic condition. A urinalysis helps detect blood in the urine (hematuria)...
325
01:25Urinary Tract Calculi VI: Surgical Management
836
Procedures for Kidney StonesMedical intervention is necessary when kidney stones or renal calculi are too large to pass spontaneously (typically greater than 5 millimeters) when stones are accompanied by symptomatic infection (such as fever or pyelonephritis), when they impair kidney function, or when they cause persistent symptoms like severe pain, nausea, or urinary retention. Additionally, patients with only one kidney or those who cannot be treated with medical management also require...
836
01:28Urinary Tract Calculi V: Nursing Management
425
AssessmentSubjective Data: Obtain a detailed health history, including any recent or chronic urinary tract infections, periods of immobilization, previous episodes of renal calculi, and medical conditions such as gout, benign prostatic hyperplasia, or hyperparathyroidism. Review the medication history for drugs that may influence stone formation, including allopurinol, analgesics, loop diuretics, or thiazide diuretics. Document the use of long-term indwelling catheters and any past surgical...
425