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Updated: Apr 1, 2026

Solubility of Hydrophobic Compounds in Aqueous Solution Using Combinations of Self-assembling Peptide and Amino Acid
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Curcumin phytosomal softgel formulation: Development, optimization and physicochemical characterization.

Ahmed N Allam, Ibrahim A Komeil, Ossama Y Abdallah

    Acta Pharmaceutica (Zagreb, Croatia)
    |October 3, 2015
    PubMed
    Summary

    Curcumin phytosomes were developed into softgels to improve bioavailability. Formulations using hydrophilic vehicles maintained stable curcumin dissolution, unlike those with oily vehicles.

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    Area of Science:

    • Pharmacology
    • Materials Science
    • Drug Delivery

    Background:

    • Curcumin, a lipophilic molecule, has diverse bioactivities but suffers from poor bioavailability due to low aqueous solubility and extensive metabolism.
    • Phytosomes are advanced drug delivery systems designed to enhance the bioavailability of poorly soluble compounds like curcumin.

    Purpose of the Study:

    • To develop and characterize curcumin phytosomes in semisolid formulations for enhanced curcumin content in softgels.
    • To evaluate the impact of different vehicles on the stability and in vitro dissolution of curcumin phytosomes in softgel formulations.

    Main Methods:

    • Curcumin phytosomes were prepared using a solvent evaporation method.
    • Thirteen softgel formulations were developed incorporating various oils, hydrophilic vehicles (PEG 400), and surfactants (Cremophor EL, KLS P 124).
    • Formulations were characterized for drug content, zeta potential, and in vitro dissolution; TEM was used to assess phytosome structure and stability.

    Main Results:

    • Transmission Electron Microscopy (TEM) confirmed the stability and spherical structure of curcumin phytosomes within complex formulations.
    • Softgel formulations utilizing a hydrophilic vehicle (PEG 400) demonstrated a stable curcumin dissolution profile over time.
    • Conversely, phytosomes formulated with oily vehicles (Miglyol 812, castor oil, oleic acid) exhibited a significant reduction in curcumin dissolution.

    Conclusions:

    • Curcumin phytosomes can be successfully incorporated into semisolid formulations for softgel delivery.
    • Hydrophilic vehicles are superior to oily vehicles for maintaining the dissolution stability of curcumin phytosomes in softgel formulations.
    • This study highlights the importance of vehicle selection in optimizing the oral delivery and therapeutic efficacy of curcumin phytosomes.