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A highly potent insulin: des-(B26-B30)-[AspB10,TyrB25-NH2]insulin(human)
G P Schwartz1, G T Burke, P G Katsoyannis
1Department of Biochemistry, Mount Sinai School of Medicine, City University of New York, NY 10029.
Abstract:
An insulin analogue that embodies two distinct structural modifications, each of which independently increases insulin activity, has been synthesized and evaluated for biological activity. The analogue, des-(B26-B30)-[AspB10,TyrB25-NH2]insulin is the most potent insulin analogue yet described; it displays an 11- to 13-fold higher activity than natural insulin. The findings are discussed with regard to the receptor-binding domains of insulin.