Related Experiment Videos
A yeast actin-binding protein is encoded by SAC6, a gene found by suppression of an actin mutation
A E Adams1, D Botstein, D G Drubin
1Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139.
Science (New York, N.Y.)
|January 13, 1989
Abstract:
The protein encoded by SAC6, a gene that can mutate to suppress a temperature-sensitive defect in the yeast actin gene, has been identified as a 67-kilodalton actin-binding protein (ABP 67) that associates with all identifiable actin structures. This finding demonstrates the in vivo functional importance of the actin-ABP 67 interaction previously established in vitro and illustrates the use of suppressor analysis to identify physically interacting proteins.