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Low bone mineral density is associated with intracranial posterior circulation atherosclerosis in women

K Kang1

  • 1Department of Neurology, Eulji General Hospital, Eulji University, Seoul, Republic of Korea; Department of Neurology, Gyeongsang National University Hospital, Jinju, Republic of Korea.

Bone
|October 4, 2015
PubMed

Insights

Low bone mineral density (BMD) is linked to intracranial atherosclerosis in women’s posterior circulation but not anterior circulation. This association was not observed in men, suggesting sex-specific differences in bone health and cerebrovascular disease.

Area of Science:

  • Neurology
  • Radiology
  • Endocrinology

Background:

  • Low bone mineral density (BMD) is a known risk factor for carotid atherosclerosis and stroke.
  • The relationship between BMD and intracranial atherosclerosis (IC Atherosclerosis) remains understudied.

Purpose of the Study:

  • To investigate the association between BMD and IC Atherosclerosis in different intracranial arteries.
  • To explore potential sex differences in this association.

Main Methods:

  • 357 participants underwent dual-energy X-ray absorptiometry for BMD assessment and 3D time-of-flight magnetic resonance angiography for IC Atherosclerosis evaluation.
  • Intracranial arteries assessed included basilar, middle cerebral, intracranial internal carotid, and intracranial vertebral arteries.
  • Low BMD was defined as a T-score < -1, with analyses stratified by sex and IC Atherosclerosis location (anterior vs. posterior circulation).

Main Results:

  • In women, low BMD was significantly associated with IC Atherosclerosis in the posterior circulation (OR 2.57; 95% CI 1.11-5.99).
  • No significant association was found between low BMD and IC Atherosclerosis in the anterior circulation in women.
  • No significant associations between BMD and IC Atherosclerosis were observed in men.

Conclusions:

  • Low BMD is associated with subclinical posterior circulation intracranial atherosclerosis in women.
  • This association appears to be sex-specific, as it was not found in men.
  • Findings suggest a potential link between bone health and cerebrovascular disease, particularly in women's posterior circulation.

Keywords:
Bone mineral density;Brain magnetic resonance angiography;Intracranial atherosclerosis;Osteoporosis;Phosphate

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