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Segmental pancreatic autotransplantation in the pig
M H Shokouh-Amiri1, S Rahimi-Saber, H O Andersen
1Department of Surgical Gastroenterology C, Rigshospitalet, University of Copenhagen, Denmark.
Transplantation
|January 1, 1989
Summary
Pigs can be suitable for pancreatic autotransplantation research. Understanding variations in pancreatic artery supply is key to successful segmental pancreatic grafts in pigs.
Area of Science:
- Surgical research
- Transplantation immunology
- Veterinary surgery
Background:
- Pigs have historically been deemed unsuitable for experimental pancreatic transplantation.
- Variations in pancreatic vascular anatomy present challenges for transplantation models.
Purpose of the Study:
- To investigate the vascular anatomy of the pig pancreas.
- To develop a successful model for segmental pancreatic autotransplantation in pigs.
Main Methods:
- Vascular anatomy of 41 pigs was studied, noting arterial supply variations.
- Segmental pancreatic autotransplantation (body and tail) was performed in 37 pigs.
- Pancreatic duct occlusion and varied venous anastomosis techniques were employed.
Main Results:
- Three types of pancreatic arterial supply variations were identified.
- Successful autotransplantation rates were 68.42% (portal vein) and 72.22% (renal vessels).
- All surviving transplanted pigs remained normoglycemic with a median follow-up of 9 months.
Conclusions:
- The pig is a suitable model for experimental pancreatic autotransplantation.
- Addressing anatomical vascular variations is crucial for successful pancreatic transplantation in pigs.