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Investigating Aortic Valve Calcification via Isolation and Culture of T Lymphocytes using Feeder Cells from Irradiated Buffy Coat
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Calcific aortic valve disease: is it another face of atherosclerosis?

I Sathyamurthy1, Shaji Alex2

  • 1Interventional Cardiologist, Apollo Main Hospitals, Chennai, India.

Indian Heart Journal
|October 4, 2015
PubMed

Insights

Calcific aortic valve disease (CAVD) shares pathological similarities with atherosclerosis. Understanding this link may help prevent aortic stenosis progression by managing risk factors and using statins.

Area of Science:

  • Cardiology
  • Pathology

Background:

  • Calcific aortic valve disease (CAVD) is the most prevalent valvular heart disease in older adults, with rising prevalence due to increased life expectancy.
  • CAVD involves progressive calcification of aortic valve cusps, sharing initial pathogenic steps with atherosclerosis, including inflammation and lipid deposition.

Purpose of the Study:

  • To explore the relationship between atherosclerosis and calcific aortic valve disease.
  • To highlight shared risk factors and pathogenic mechanisms between vascular and valvular atherosclerosis.

Main Methods:

  • This review synthesizes historical, experimental, genetic, and clinical evidence.
  • It examines the shared pathological sequences and risk factors between CAVD and atherosclerosis.

Main Results:

  • CAVD and atherosclerosis exhibit similar pathological processes, including basement membrane disruption, inflammation, and calcification.
  • Osteopontin presence in calcified valves indicates pathological calcification and bone formation, mirroring processes in atherosclerosis.

Conclusions:

  • Recognizing CAVD as a manifestation of valvular atherosclerosis is crucial.
  • Controlling modifiable risk factors and considering statin therapy may prevent the progression from aortic sclerosis to aortic stenosis.

Keywords:
AtherosclerosisCalcific aortic stenosisDegenerative aortic stenosis

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